PDIA3, protein disulfide isomerase family A member 3

PDIA3, protein disulfide isomerase family A member 3

• This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

• Gene Synonyms (protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, ER protein 57, ER protein 60, disulfide isomerase ER-60, endoplasmic reticulum P58, endoplasmic reticulum resident protein 57, endoplasmic reticulum resident protein 60, epididymis secretory protein Li 269, epididymis secretory sperm binding protein Li 93n, glucose regulated protein, 58kDa, phospholipase C-alpha, protein disulfide isomerase-associated 3, ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC,)
• NCBI Gene ID: 2923
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30101
  UNIPROT ID#>>V9HVY3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein disulfide isomerase family A member 3 interacts with:

• AAR2 splicing factor
  acyl-CoA thioesterase 7
  ADAM metallopeptidase domain 17
  agrin
  aminopeptidase puromycin sensitive
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily E member 1
  ATP synthase peripheral stalk subunit d
  ATPase H+ transporting accessory protein 2
  autophagy related 16 like 1
  beta-secretase 1
  BRCA2 and CDKN1A interacting protein
  calreticulin 3
  carnosine dipeptidase 2
  centriolin
  coiled-coil domain containing 8
  cornulin
  coronin 1C
  cullin 7
  DEAD-box helicase 17
  discoidin, CUB and LCCL domain containing 1
  dual specificity phosphatase 13
  elongation factor Tu GTP binding domain containing 2
  endoplasmic reticulum oxidoreductase 1 alpha
  endoplasmic reticulum oxidoreductase 1 beta
  endoplasmic reticulum protein 27
  ER degradation enhancing alpha-mannosidase like protein 3
  eukaryotic translation initiation factor 5B
  expressed sequence AI837181
  Fas binding factor 1
  galectin 9
  glycogen synthase kinase 3 beta
  glycophorin C (Gerbich blood group)
  golgi transport 1B
  H3 clustered histone 15
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family D (Hsp60) member 1
  heterogeneous nuclear ribonucleoprotein K
  high mobility group box 1
  histone deacetylase 10
  histone deacetylase 4
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  hydroxymethylbilane synthase
  inhibin subunit alpha
  insulin receptor
  integrin beta 1 (fibronectin receptor beta)
  integrin subunit alpha 2
  integrin subunit alpha 3
  integrin subunit alpha 6
  integrin subunit beta 1
  integrin subunit beta 5
  interferon gamma
  isocitrate dehydrogenase (NADP(+)) 2
  jumonji domain containing 8
  kelch repeat and BTB domain containing 7
  lactate dehydrogenase A
  laminin subunit beta 1
  laminin subunit beta 3
  laminin subunit gamma 1
  laminin subunit gamma 2
  leucine rich repeat kinase 2
  low density lipoprotein receptor
  lysyl oxidase like 2
  major histocompatibility complex, class I, A
  major histocompatibility complex, class I, B
  MDM2 proto-oncogene
  melanotransferrin
  melatonin receptor 1B
  methylthioadenosine phosphorylase
  methyltransferase like 14
  minichromosome maintenance complex component 2
  mitochondrial ribosomal protein L12
  mitogen-activated protein kinase 13
  MYC proto-oncogene, bHLH transcription factor
  myotrophin
  myristoylated alanine rich protein kinase C substrate
  N-acetylneuraminate synthase
  neurotrophic receptor tyrosine kinase 1
  NHL repeat containing 2
  NIMA (never in mitosis gene a)-related expressed kinase 2
  NMD3 ribosome export adaptor
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  p21 (RAC1) activated kinase 2
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  peptidylprolyl isomerase B
  pescadillo ribosomal biogenesis factor 1
  phosphoethanolamine/phosphocholine phosphatase 1
  phosphogluconate dehydrogenase
  phospholipase A2 activating protein
  PIH1 domain containing 1
  plasminogen receptor with a C-terminal lysine
  pleckstrin homology domain containing A4
  plexin A1
  pre-mRNA processing factor 8
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  proliferation-associated 2G4
  prolyl 4-hydroxylase subunit beta
  proteasome 20S subunit beta 5
  protein disulfide isomerase family A member 4
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase receptor type H
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type O
  protein tyrosine phosphatase receptor type U
  pyrimidinergic receptor P2Y6
  pyruvate dehydrogenase E1 subunit alpha 1
  RAB1A, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAD23 homolog B, nucleotide excision repair protein
  RB binding protein 4, chromatin remodeling factor
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ribophorin II
  ribosomal protein L23
  ring finger protein 4
  RPTOR independent companion of MTOR complex 2
  SEC61 translocon subunit alpha 1
  signal transducer and activator of transcription 3
  SLC9A3 regulator 1
  small nuclear ribonucleoprotein polypeptide B2
  small ubiquitin like modifier 4
  solute carrier family 12 member 3
  solute carrier family 2 member 1
  spermine synthase
  staphylococcal nuclease and tudor domain containing 1
  sterol O-acyltransferase 1
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  SUZ12 polycomb repressive complex 2 subunit
  synoviolin 1
  TAP binding protein
  TAR DNA binding protein
  taxilin alpha
  T-box transcription factor 3
  tectonic family member 1
  tectonic family member 3
  TNF receptor associated protein 1
  transforming growth factor beta 1
  transforming growth factor, beta receptor I
  transgelin 2
  transmembrane p24 trafficking protein 10
  transporter 1, ATP binding cassette subfamily B member
  triokinase and FMN cyclase
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  unk zinc finger
  valosin containing protein
  vimentin
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  zinc finger protein 207

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.