HSPA5, heat shock protein family A (Hsp70) member 5

HSPA5, heat shock protein family A (Hsp70) member 5

• The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

• Gene Synonyms (endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, HSP70 family protein 5, binding-immunoglobulin protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, glucose-regulated protein, 78kDa, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), heat shock protein 70 family protein 5, heat shock protein family A member 5, immunoglobulin heavy chain-binding protein, BIP, GRP78, HEL-S-89n, MIF2,)
• NCBI Gene ID: 3309
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HWB4
  UNIPROT ID#>>P11021
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family A (Hsp70) member 5 interacts with:

• 5-hydroxytryptamine receptor 3A
  AAR2 splicing factor
  activation induced cytidine deaminase
  activator of HSP90 ATPase activity 1
  ADAM metallopeptidase domain 21
  ADAM metallopeptidase with thrombospondin type 1 motif 18
  adenosylhomocysteinase like 1
  AHNAK nucleoprotein
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  angiopoietin like 2
  anoctamin 3
  anterior gradient 2, protein disulphide isomerase family member
  ANTXR cell adhesion molecule 1
  AP2 associated kinase 1
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 2
  armadillo repeat containing 12
  arylsulfatase family member I
  astacin like metalloendopeptidase
  ataxin 1
  ataxin 3
  ATP binding cassette subfamily F member 3
  ATP synthase peripheral stalk subunit d
  aurora kinase A
  aurora kinase B
  autophagy and beclin 1 regulator 1
  B cell receptor associated protein 31
  BAG cochaperone 2
  BAG cochaperone 3
  BAG cochaperone 6
  BCAR1 scaffold protein, Cas family member
  beclin 1
  beta-1,4-galactosyltransferase 4
  brain abundant membrane attached signal protein 1
  bromodomain containing 7
  calmodulin-lysine N-methyltransferase
  calreticulin 3
  carboxypeptidase A5
  caspase 12 (gene/pseudogene)
  CCCTC-binding factor
  CDKN2A interacting protein
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  centrosomal protein 250
  centrosomal protein 57
  centrosomal protein 70
  centrosomal protein 72
  centrosomal protein 76
  clusterin associated protein 1
  coiled-coil domain containing 8
  coiled-coil-helix-coiled-coil-helix domain containing 3
  collectin subfamily member 11
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  CREB regulated transcription coactivator 3
  C-type lectin domain containing 14A
  C-type lectin domain family 18 member A
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin J like
  cytochrome c oxidase subunit 5A
  cytoskeleton associated protein 5
  DDB1 and CUL4 associated factor 4 like 2
  DEAD-box helicase 24
  decapping enzyme, scavenger
  defective in cullin neddylation 1 domain containing 1
  desert hedgehog signaling molecule
  DGCR8 microprocessor complex subunit
  dihydropyrimidinase like 5
  dipeptidase 3
  DNA topoisomerase II binding protein 1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A4
  DnaJ heat shock protein family (Hsp40) member B1
  DnaJ heat shock protein family (Hsp40) member B11
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member B9
  DnaJ heat shock protein family (Hsp40) member C1
  DnaJ heat shock protein family (Hsp40) member C10
  DnaJ heat shock protein family (Hsp40) member C17
  DnaJ heat shock protein family (Hsp40) member C19
  DnaJ heat shock protein family (Hsp40) member C2
  DnaJ heat shock protein family (Hsp40) member C3
  DnaJ heat shock protein family (Hsp40) member C7
  DnaJ heat shock protein family (Hsp40) member C8
  DnaJ heat shock protein family (Hsp40) member C9
  dual specificity tyrosine phosphorylation regulated kinase 2
  EEF1A lysine methyltransferase 3
  EGF like domain multiple 6
  electron transfer flavoprotein subunit beta lysine methyltransferase
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endoplasmic reticulum lectin 1
  endoplasmic reticulum protein 29
  enhancer of mRNA decapping 4
  epididymal peptidase inhibitor
  ER degradation enhancing alpha-mannosidase like protein 3
  ER lipid raft associated 2
  eukaryotic elongation factor 2 lysine methyltransferase
  eukaryotic translation initiation factor 2 alpha kinase 3
  exportin 5
  family with sequence similarity 187 member B
  Fas associated factor 1
  Fas associated factor family member 2
  F-box protein 25
  F-box protein 6
  F-box protein 7
  FCH and double SH3 domains 2
  fibulin 7
  FKBP prolyl isomerase 9
  folliculin interacting protein 1
  galactosidase beta 1 like 2
  galactosidase beta 1 like 3
  galectin 1
  galectin 3 binding protein
  GLI pathogenesis related 1
  glycosyltransferase 8 domain containing 2
  growth hormone inducible transmembrane protein
  H3 clustered histone 6
  H4 clustered histone 1
  HAUS augmin like complex subunit 2
  HCLS1 associated protein X-1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  heat shock protein family H (Hsp110) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heparan sulfate-glucosamine 3-sulfotransferase 2
  hes related family bHLH transcription factor with YRPW motif 1
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  HNF1 homeobox B
  HSPA (Hsp70) binding protein 1
  hyaluronan and proteoglycan link protein 3
  hypoxia up-regulated 1
  iduronate 2-sulfatase
  immunoglobulin superfamily containing leucine rich repeat
  inhibin subunit alpha
  inhibin subunit beta E
  inhibitor of DNA binding 2
  inhibitor of growth family member 3
  inositol polyphosphate phosphatase like 1
  insulin induced gene 2
  insulin like 6
  insulin like growth factor 1 receptor
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 9
  intelectin 1
  intercellular adhesion molecule 1
  interleukin 12 receptor subunit beta 1
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  IQ motif containing B1
  IQ motif containing GTPase activating protein 1
  IST1 factor associated with ESCRT-III
  junction plakoglobin
  karyopherin subunit beta 1
  keratin 14
  keratin 17
  keratin 18
  keratin 8
  KIAA2013
  kinase suppressor of ras 1
  kinetochore localized astrin (SPAG5) binding protein
  La ribonucleoprotein 7, transcriptional regulator
  lactase
  lactate dehydrogenase A like 6B
  laminin subunit alpha 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  LDL receptor related protein 1
  leucine rich repeat kinase 2
  LIM domain containing preferred translocation partner in lipoma
  low density lipoprotein receptor
  LY6/PLAUR domain containing 1
  lysosomal associated membrane protein 1
  lysozyme like 2
  lysyl oxidase like 3
  MAGE family member D2
  megakaryocyte-associated tyrosine kinase
  melatonin receptor 1A
  melatonin receptor 1B
  metallophosphoesterase 1
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 18
  methyltransferase like 21A
  methyltransferase like 21C
  methyltransferase like 22
  methyltransferase like 23
  methyltransferase like 3
  mex-3 RNA binding family member C
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein 4
  microtubule associated protein RP/EB family member 1
  microtubule associated protein tau
  minichromosome maintenance complex component 2
  mitochondrial carrier 2
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 7
  moesin
  Mov10 RISC complex RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  myogenesis regulating glycosidase (putative)
  myosin heavy chain 10
  myosin heavy chain 9
  N-6 adenine-specific DNA methyltransferase 1
  napsin A aspartic peptidase
  NCK adaptor protein 1
  NEDD8 ubiquitin like modifier
  negative regulator of reactive oxygen species
  neuronal vesicle trafficking associated 2
  neuropeptide B
  neurotrophic receptor tyrosine kinase 1
  NIMA related kinase 2
  nitric oxide synthase 2
  N-myc downstream regulated 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear receptor coactivator 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleobindin 1
  nucleophosmin 1
  nucleoporin 62
  nyctalopin
  obscurin like cytoskeletal adaptor 1
  OCIA domain containing 1
  OS9 endoplasmic reticulum lectin
  O-sialoglycoprotein endopeptidase
  OTU deubiquitinase 3
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  p21 (RAC1) activated kinase 2
  palladin, cytoskeletal associated protein
  palmitoyl-protein thioesterase 1
  paraoxonase 2
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  patched 1
  peptidylprolyl isomerase B
  peptidylprolyl isomerase E
  peroxiredoxin 3
  peroxisome proliferator activated receptor gamma
  phosphatidylinositol 3-kinase catalytic subunit type 3
  phosphodiesterase 3A
  PIH1 domain containing 1
  platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  pleckstrin homology domain containing A4
  podocalyxin like
  podocan
  poly(A) specific ribonuclease subunit PAN2
  polypyrimidine tract binding protein 1
  potassium channel tetramerization domain containing 15
  potassium voltage-gated channel subfamily D member 3
  PR/SET domain 16
  pre-mRNA processing factor 8
  presenilin 1
  presequence translocase associated motor 16
  prion protein
  pro-apoptotic WT1 regulator
  prohibitin
  prohibitin 2
  prolyl 4-hydroxylase subunit alpha 3
  prolyl 4-hydroxylase subunit beta
  proprotein convertase subtilisin/kexin type 7
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, non-ATPase 1
  proteasome activator subunit 3
  proteasome subunit alpha 2
  protein disulfide isomerase family A member 6
  protein inhibitor of activated STAT 1
  protein kinase C and casein kinase substrate in neurons 3
  protein kinase C substrate 80K-H
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 4 regulatory subunit 4
  protein phosphatase 6 catalytic subunit
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase receptor type F
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type N2
  protein tyrosine phosphatase receptor type O
  protein Z, vitamin K dependent plasma glycoprotein
  protocadherin alpha 10
  PTEN induced kinase 1
  PWP1 homolog, endonuclein
  pyruvate dehydrogenase E1 subunit beta
  RAB11A, member RAS oncogene family
  RAB14, member RAS oncogene family
  RAB7A, member RAS oncogene family
  Rac family small GTPase 3
  Raf-1 proto-oncogene, serine/threonine kinase
  Rap1 GTPase-GDP dissociation stimulator 1
  RE1 silencing transcription factor
  RecQ like helicase 4
  regulator of microtubule dynamics 3
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  replication protein A2
  replication protein A3
  resistin
  reticulocalbin 1
  reticulocalbin 2
  ribophorin I
  ribosomal protein L23
  ribosomal protein L8
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S16
  ribosomal protein S25
  ribosomal protein S3
  ribosomal protein S6 kinase B2
  ribosomal protein SA
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 146
  ring finger protein 31
  ring finger protein 4
  ring finger protein 40
  ring-box 1
  RIO kinase 1
  RNA exonuclease 2
  RNA polymerase III subunit H
  RuvB like AAA ATPase 2
  saccharopine dehydrogenase (putative)
  SEC61 translocon subunit alpha 1
  SEC63 homolog, protein translocation regulator
  secretoglobin family 1D member 1
  secretoglobin family 1D member 4
  SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
  septin 10
  septin 2
  septin 6
  septin 9
  sequestosome 1
  serine hydroxymethyltransferase 2
  serine protease 2
  serine protease 50
  serine/arginine repetitive matrix 2
  serpin family A member 1
  serpin family B member 11
  serpin family B member 5
  serpin family F member 1
  SH3 domain binding protein 4
  SHC adaptor protein 1
  sialic acid binding Ig like lectin 10
  sialic acid binding Ig like lectin 12
  signal regulatory protein alpha
  signal sequence receptor subunit 1
  SIL1 nucleotide exchange factor
  single stranded DNA binding protein 1
  sirtuin 1
  sirtuin 3
  SKI proto-oncogene
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein U1 subunit 70
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 24
  spartin
  spectrin alpha, non-erythrocytic 1
  spectrin beta, non-erythrocytic 1
  sperm acrosome associated 3
  sperm acrosome associated 4
  spindle apparatus coiled-coil protein 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  ST3 beta-galactoside alpha-2,3-sialyltransferase 2
  stathmin 1
  staufen double-stranded RNA binding protein 1
  sterol regulatory element binding transcription factor 2
  STIP1 homology and U-box containing protein 1
  stomatin like 2
  stress induced phosphoprotein 1
  stromal cell derived factor 2
  stromal cell derived factor 4
  SUB1 regulator of transcription
  surfactant protein C
  surfeit 4
  synaptophysin like 2
  synoviolin 1
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  TEPSIN adaptor related protein complex 4 accessory protein
  teratocarcinoma-derived growth factor 1
  testis expressed 101
  testis, prostate and placenta expressed
  thioredoxin
  thioredoxin reductase 1
  thymopoietin
  thyroglobulin
  thyroid stimulating hormone receptor
  thyroid stimulating hormone subunit beta
  TNF receptor associated protein 1
  torsin family 3 member A
  trafficking from ER to golgi regulator
  TRAF-type zinc finger domain containing 1
  transcription elongation regulator 1
  transcription factor CP2
  transcriptional adaptor 2A
  transforming growth factor beta 1
  transgelin 2
  transglutaminase 2
  translocase of inner mitochondrial membrane 13
  transmembrane protein 132A
  transmembrane protein 25
  transmembrane protein 263
  transmembrane protein 62
  transmembrane protein 67
  tripartite motif containing 25
  tripartite motif containing 29
  tripartite motif containing 44
  tropomodulin 3
  tubulin alpha 4a
  tubulin alpha 4b
  tubulin beta 4A class IVa
  tubulin gamma 1
  tubulin gamma complex associated protein 2
  tubulin gamma complex associated protein 3
  tubulin gamma complex associated protein 4
  tubulointerstitial nephritis antigen
  tumor necrosis factor
  tumor protein p53
  tumor protein p63
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquilin 4
  ubiquinol-cytochrome c reductase binding protein
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 S
  ubiquitin C-terminal hydrolase L5
  ubiquitin like 4A
  ubiquitin like 7
  ubiquitin protein ligase E3A
  UBX domain protein 1
  uroplakin 3B
  valosin containing protein
  vimentin
  vinculin
  vir like m6A methyltransferase associated
  vitrin
  von Hippel-Lindau tumor suppressor
  von Willebrand factor
  von Willebrand factor C and EGF domains
  V-set and immunoglobulin domain containing 8
  WASP family member 3
  Wnt family member 2
  Wnt family member 3A
  Wnt family member 4
  Wnt family member 7A
  Wnt family member 9B
  WT1 associated protein
  WW domain containing E3 ubiquitin protein ligase 2
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  YY1 transcription factor
  zinc finger and BTB domain containing 25
  zinc finger containing ubiquitin peptidase 1
  zinc finger FYVE-type containing 21
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger SWIM-type containing 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.