IRF3, interferon regulatory factor 3

IRF3, interferon regulatory factor 3

• This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important in the innate immune response against DNA and RNA viruses. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2020]

• Gene Synonyms (IIAE7, interferon regulatory factor 3,)
• NCBI Gene ID: 3661
• Species: Homo sapiens (Human)
• UNIPROT ID#>>M0QYT9
  UNIPROT ID#>>E2GIM8
  UNIPROT ID#>>E2GIM7
  UNIPROT ID#>>E2GIM9
  UNIPROT ID#>>E2GIM5
  UNIPROT ID#>>E2GIM6
  UNIPROT ID#>>Q14653
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interferon regulatory factor 3 interacts with:

• acetylserotonin O-methyltransferase like
  adhesion G protein-coupled receptor L2
  ankyrin repeat domain 40
  BCAS3 microtubule associated cell migration factor
  chromosome 5 open reading frame 34
  coiled-coil domain containing 88A
  cullin 1
  cyclin dependent kinase like 2
  DEAF1 transcription factor
  dedicator of cytokinesis 7
  DExD/H-box helicase 58
  diphosphoinositol pentakisphosphate kinase 1
  exportin 1
  extended synaptotagmin 2
  F-box protein 17
  F-box protein 6
  F-box protein 7
  FKBP prolyl isomerase 8
  glomulin, FKBP associated protein
  glutamate receptor interacting protein 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  histone deacetylase 3
  importin 5
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  interferon regulatory factor 3
  interferon regulatory factor 5
  interferon regulatory factor 7
  KIT proto-oncogene, receptor tyrosine kinase
  MAF bZIP transcription factor B
  methionine sulfoxide reductase A
  mitochondrial antiviral signaling protein
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase kinase 14
  molybdenum cofactor sulfurase
  OTU deubiquitinase 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase B
  peroxiredoxin 1
  peroxisomal biogenesis factor 19
  proteasome 20S subunit alpha 5
  protein inhibitor of activated STAT 4
  protein phosphatase 2 catalytic subunit alpha
  PTEN induced kinase 1
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  RB transcriptional corepressor like 2
  RELA proto-oncogene, NF-kB subunit
  RNA polymerase II subunit A
  sarcolemma associated protein
  serpin family B member 2
  SMAD family member 2
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 2
  small glutamine rich tetratricopeptide repeat containing alpha
  sortilin 1
  spalt like transcription factor 2
  stimulator of interferon response cGAMP interactor 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 2
  suppressor of cytokine signaling 1
  synaptogyrin 3
  synaptotagmin 1
  TANK binding kinase 1
  testis expressed 36
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  toll like receptor 2
  toll like receptor adaptor molecule 1
  toll like receptor adaptor molecule 2
  TRAF family member associated NFKB activator
  TRAF3 interacting protein 2
  translocase of outer mitochondrial membrane 70
  tripartite motif containing 21
  tripartite motif containing 25
  tripartite motif containing 26
  trophinin
  tubulin beta 8 class VIII
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 19
  unc-51 like autophagy activating kinase 1
  WD repeat domain 82
  WRN helicase interacting protein 1
  Yes1 associated transcriptional regulator
  zinc finger CCCH-type containing 12A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.