TNPO1, transportin 1

TNPO1, transportin 1

• This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]

• Gene Synonyms (IPO2, KPNB2, MIP, MIP1, TRN, transportin-1, M9 region interaction protein, importin 2, importin beta 2, karyopherin (importin) beta 2, karyopherin beta-2,)
• NCBI Gene ID: 3842
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92973
  UNIPROT ID#>>A0A024RAM0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transportin 1 interacts with:

• A-kinase anchoring protein 5
  ATPase, Cu++ transporting, alpha polypeptide
  CD274 molecule
  chaperonin containing Tcp1, subunit 3 (gamma)
  chaperonin containing Tcp1, subunit 8 (theta)
  chromobox 4
  coiled-coil domain containing 8
  cullin 7
  dual specificity phosphatase 23
  egl-9 family hypoxia inducible factor 3
  G3BP stress granule assembly factor 1
  GAR1 ribonucleoprotein
  H2B clustered histone 21
  H3.4 histone
  histone deacetylase 5
  importin 4
  importin 5
  importin 7
  importin 8
  importin 9
  jun B proto-oncogene
  KRAS proto-oncogene, GTPase
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  lysine demethylase 6B
  membrane bound O-acyltransferase domain containing 1
  membrane metalloendopeptidase
  myristoylated alanine rich protein kinase C substrate
  necdin, MAGE family member
  neurotrophic receptor tyrosine kinase 1
  NHL repeat containing 2
  notch receptor 1
  nuclear factor of activated T cells 2
  nuclear RNA export factor 1
  nucleoporin 153
  nucleoporin 214
  nucleoporin 98 and 96 precursor
  obscurin like cytoskeletal adaptor 1
  phosphorylase kinase catalytic subunit gamma 2
  pleckstrin homology domain containing A4
  poly(A) binding protein nuclear 1
  potassium channel tetramerisation domain containing 5
  potassium channel, subfamily K, member 1
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit alpha
  protein tyrosine phosphatase mitochondrial 1
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type E
  protein tyrosine phosphatase receptor type H
  protein tyrosine phosphatase receptor type M
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type N2
  pyrimidinergic receptor P2Y6
  RAN binding protein 2
  RAN binding protein 6
  RAN, member RAS oncogene family
  RANBP2 like and GRIP domain containing 5
  RecQ like helicase 4
  ribonucleotide reductase catalytic subunit M1
  ribosomal protein L23a
  ribosomal protein L5
  ribosomal protein S7
  ring finger protein 4
  SIGLEC family like 1
  signal recognition particle 19
  sirtuin 7
  small nuclear ribonucleoprotein polypeptide A
  solute carrier family 15 member 3
  spindle apparatus coiled-coil protein 1
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  STIL centriolar assembly protein
  SUN domain containing ossification factor
  suppressor of cytokine signaling 6
  TEPSIN adaptor related protein complex 4 accessory protein
  thioredoxin reductase 1
  TNF superfamily member 13b
  trafficking regulator of GLUT4 (SLC2A4) 1
  transcription elongation factor A2
  translation machinery associated 16 homolog
  transmembrane protein 255A
  transmembrane protein 63B
  transportin 1
  transportin 3
  tripartite motif containing 25
  tubulin alpha 4a
  tubulin beta 3 class III
  unc-51 like autophagy activating kinase 2
  unc-93 homolog B1, TLR signaling regulator
  VHL binding protein 1
  vir like m6A methyltransferase associated
  VPS16 core subunit of CORVET and HOPS complexes
  V-set and immunoglobulin domain containing 2
  WD repeat containing antisense to TP53
  WW domain containing oxidoreductase
  X-ray repair cross complementing 3
  YY1 associated factor 2
  zinc finger and BTB domain containing 38
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.