MAP3K5, mitogen-activated protein kinase kinase kinase 5

MAP3K5, mitogen-activated protein kinase kinase kinase 5

• Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, ASK-1, MAP/ERK kinase kinase 5, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, apoptosis signal-regulating kinase 1,)
• NCBI Gene ID: 4217
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99683
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 5 interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3G
  apoptosis inducing factor mitochondria associated 1
  ATPase family AAA domain containing 3A
  aurora kinase A
  beta-transducin repeat containing E3 ubiquitin protein ligase
  calcium and integrin binding 1
  CASP8 and FADD like apoptosis regulator
  cullin 4A
  DAB2 interacting protein
  dual specificity phosphatase 19
  egl-9 family hypoxia inducible factor 3
  eukaryotic translation initiation factor 2 alpha kinase 2
  F-box and WD repeat domain containing 11
  fizzy and cell division cycle 20 related 1
  G protein subunit alpha 13
  gem nuclear organelle associated protein 5
  GLIS family zinc finger 2
  glutaminyl-tRNA synthetase 1
  glutathione S-transferase, mu 1
  growth arrest and DNA damage inducible beta
  large tumor suppressor kinase 2
  lysine methyltransferase 2A
  maternal embryonic leucine zipper kinase
  microspherule protein 1
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 6
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 5
  mitogen-activated protein kinase kinase kinase 6
  mitogen-activated protein kinase kinase kinase 7
  myelin basic protein
  NEDD4 E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  neurofibromin 2
  neuropeptide Y receptor Y4
  nucleus accumbens associated 1
  Parkinsonism associated deglycase
  phosphoinositide-3-kinase regulatory subunit 1
  programmed cell death 6
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase AMP-activated non-catalytic subunit beta 2
  protein kinase AMP-activated non-catalytic subunit gamma 1
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein phosphatase 3 regulatory subunit B, alpha
  protein phosphatase 5 catalytic subunit
  protein tyrosine phosphatase non-receptor type 11
  pyrimidinergic receptor P2Y6
  Raf-1 proto-oncogene, serine/threonine kinase
  RB1 inducible coiled-coil 1
  RB1-inducible coiled-coil 1
  serine/threonine kinase 11
  siah E3 ubiquitin protein ligase 1
  STIP1 homology and U-box containing protein 1
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  survival of motor neuron 1, telomeric
  TEA domain transcription factor 2
  telomerase reverse transcriptase
  thioredoxin
  thioredoxin 2
  TNF alpha induced protein 3
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  TNF receptor associated factor 5
  TNF receptor associated factor 6
  TNF superfamily member 13b
  toll interacting protein
  TPD52 like 1
  TPD52 like 2
  troponin T2, cardiac type
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin specific peptidase 9 X-linked
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.