CARS1, cysteinyl-tRNA synthetase 1

CARS1, cysteinyl-tRNA synthetase 1

• This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

• Gene Synonyms (cysteine--tRNA ligase, cytoplasmic, cysteine tRNA ligase 1, cytoplasmic, cysteine translase, CARS, CYSRS, MCDDBH, MDBH, MGC:11246,)
• NCBI Gene ID: 833
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RCG3
  UNIPROT ID#>>P49589
  UNIPROT ID#>>B4DPV7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cysteinyl-tRNA synthetase 1 interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  ankyrin repeat and BTB domain containing 1
  autophagy related 16 like 1
  basic leucine zipper ATF-like transcription factor 3
  catenin beta like 1
  cullin associated and neddylation dissociated 1
  cystathionine beta-synthase
  cysteinyl-tRNA synthetase 1
  double PHD fingers 2
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation elongation factor 1 gamma
  exportin 7
  Fas associated factor 1
  general transcription factor IIE subunit 1
  glutamine--fructose-6-phosphate transaminase 1
  glycyl-tRNA synthetase 1
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 4
  heterogeneous nuclear ribonucleoprotein A1
  HIRA interacting protein 3
  insulin degrading enzyme
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  leucyl-tRNA synthetase 1
  lipopolysaccharide induced TNF factor
  LUC7 like 2, pre-mRNA splicing factor
  lysyl-tRNA synthetase 1
  MLLT6, PHD finger containing
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  neurotrophic receptor tyrosine kinase 1
  phosphatidylinositol binding clathrin assembly protein
  phosphoribosyl pyrophosphate amidotransferase
  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pro-apoptotic WT1 regulator
  proline-serine-threonine phosphatase interacting protein 1
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 12
  protein kinase C and casein kinase substrate in neurons 1
  protein kinase C and casein kinase substrate in neurons 2
  protein kinase C and casein kinase substrate in neurons 3
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  pyridoxal phosphate binding protein
  ribosomal protein L13
  Ro60, Y RNA binding protein
  SBDS ribosome maturation factor
  Sec23 homolog A, COPII coat complex component
  SEC24 homolog D, COPII coat complex component
  serine hydroxymethyltransferase 1
  small nuclear RNA activating complex polypeptide 1
  small ubiquitin like modifier 2
  splicing factor proline and glutamine rich
  staufen double-stranded RNA binding protein 1
  tetratricopeptide repeat domain 1
  THUMP domain containing 3
  TNF receptor associated factor 6
  tripartite motif containing 25
  ubiquitin like modifier activating enzyme 2
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.