CHD3, chromodomain helicase DNA binding protein 3

CHD3, chromodomain helicase DNA binding protein 3

• This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (chromodomain-helicase-DNA-binding protein 3, ATP-dependent helicase CHD3, CHD-3, hZFH, mi-2 autoantigen 240 kDa protein, zinc finger helicase, zinc-finger helicase (Snf2-like), Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH,)
• NCBI Gene ID: 1107
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KWV4
  UNIPROT ID#>>Q2TAZ1
  UNIPROT ID#>>Q12873
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chromodomain helicase DNA binding protein 3 interacts with:

• 5'-3' exoribonuclease 2
  actin related protein 1B
  activating signal cointegrator 1 complex subunit 2
  activating signal cointegrator 1 complex subunit 3
  activity dependent neuroprotector homeobox
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  Aly/REF export factor
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  apoptosis antagonizing transcription factor
  apoptosis inhibitor 5
  apoptotic chromatin condensation inducer 1
  ATP synthase inhibitory factor subunit 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  ATPase family AAA domain containing 5
  AT-rich interaction domain 1A
  aurora kinase A interacting protein 1
  BAF chromatin remodeling complex subunit BCL11A
  BAF chromatin remodeling complex subunit BCL11B
  basic helix-loop-helix family member e40
  BCAS2 pre-mRNA processing factor
  BCL2 associated transcription factor 1
  BCL6 corepressor
  BEN domain containing 7
  biogenesis of ribosomes BRX1
  bromodomain adjacent to zinc finger domain 1A
  bromodomain adjacent to zinc finger domain 1B
  bromodomain containing 1
  bromodomain containing 2
  calcium homeostasis endoplasmic reticulum protein
  cAMP responsive element binding protein 1
  carboxypeptidase E
  casein kinase 2 alpha 1
  caspase 14
  CCAAT enhancer binding protein zeta
  CD2 cytoplasmic tail binding protein 2
  CDK2 (cyclin-dependent kinase 2)-associated protein 1
  cell cycle and apoptosis regulator 2
  cell cycle associated protein 1
  cell division cycle and apoptosis regulator 1
  centromere protein V
  chromatin target of PRMT1
  chromobox 1
  chromobox 3
  chromodomain helicase DNA binding protein 3
  chromodomain helicase DNA binding protein 4
  chromodomain helicase DNA binding protein 5
  chromodomain helicase DNA binding protein 6
  chromosome 1 open reading frame 35
  chromosome 19 open reading frame 47
  chromosome 4 open reading frame 17
  chromosome 7 open reading frame 50
  chromosome segregation 1 like
  cleavage and polyadenylation specific factor 1
  cleavage stimulation factor subunit 2
  coiled-coil domain containing 137
  coiled-coil domain containing 8
  coilin
  cortactin
  CREB binding protein
  C-terminal binding protein 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cut like homeobox 1
  cyclin dependent kinase 2 associated protein 1
  cysteine rich C-terminal 1
  DEAD-box helicase 1
  DEAD-box helicase 10
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 23
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 41
  DEAD-box helicase 42
  DEAD-box helicase 46
  DEAD-box helicase 47
  DEAD-box helicase 5
  DEAD-box helicase 51
  DEAD-box helicase 54
  DEAD-box helicase 55
  DEAD-box helicase 56
  DEAH-box helicase 15
  DEAH-box helicase 38
  dermcidin
  desmoglein 1
  desmoplakin
  developmental pluripotency-associated 3
  DExD-box helicase 21
  DExD-box helicase 39A
  DExD-box helicase 39B
  DExD-box helicase 50
  DExD-box helicase 52
  DExH-box helicase 30
  DExH-box helicase 9
  DNA ligase 3
  DNA polymerase delta interacting protein 3
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
  dyskerin pseudouridine synthase 1
  EBNA1 binding protein 2
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  elongin A
  elongin BC and polycomb repressive complex 2 associated protein
  endosome associated trafficking regulator 1
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  enolase 1
  ERH mRNA splicing and mitosis factor
  estrogen receptor 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 2 subunit alpha
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3 subunit G
  eukaryotic translation initiation factor 3 subunit L
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4A1
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 6
  EWS RNA binding protein 1
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 120A
  family with sequence similarity 98 member A
  far upstream element binding protein 1
  fatty acid binding protein 4
  fatty acid binding protein 5
  fibrillarin
  filaggrin family member 2
  FMR1 autosomal homolog 2
  FMRP translational regulator 1
  forkhead box A1
  formin binding protein 4
  fructose-bisphosphatase 2
  FtsJ RNA 2'-O-methyltransferase 3
  FUS RNA binding protein
  G protein nucleolar 2
  G protein nucleolar 3
  G protein pathway suppressor 2
  G protein subunit beta 2
  G3BP stress granule assembly factor 1
  galectin 7
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  gem nuclear organelle associated protein 4
  general transcription factor IIi
  GIT ArfGAP 1
  glutamyl-prolyl-tRNA synthetase 1
  glyceraldehyde-3-phosphate dehydrogenase
  glycogen synthase kinase 3 beta
  glyoxylate reductase 1 homolog
  G-patch domain containing 4
  growth arrest and DNA damage inducible alpha
  GTP binding protein 4
  H1.10 linker histone
  H1.2 linker histone, cluster member
  H2A clustered histone 12
  H2A clustered histone 4
  H2B clustered histone 12
  H2B clustered histone 3
  H2B clustered histone 9
  H3 clustered histone 1
  H4 clustered histone 1
  H4 clustered histone 9
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  heat shock protein family H (Hsp110) member 1
  heat shock transcription factor 1
  heat shock transcription factor Y-linked 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  HIC ZBTB transcriptional repressor 1
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  HIV-1 Tat specific factor 1
  homeobox containing 1
  hornerin
  huntingtin
  huntingtin interacting protein K
  hyaluronan binding protein 4
  hydroxysteroid 17-beta dehydrogenase 10
  IK cytokine
  IKAROS family zinc finger 1
  IKAROS family zinc finger 3
  influenza virus NS1A binding protein
  inner membrane mitochondrial protein
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  IQ motif containing GTPase activating protein 1
  isoleucyl-tRNA synthetase 1
  Jun proto-oncogene, AP-1 transcription factor subunit
  junction plakoglobin
  karyopherin subunit alpha 1
  karyopherin subunit alpha 2
  karyopherin subunit alpha 3
  karyopherin subunit beta 1
  keratin 1
  keratin 10
  keratin 14
  keratin 16
  keratin 17
  keratin 19
  keratin 2
  keratin 3
  keratin 4
  keratin 5
  keratin 6A
  keratin 6B
  keratin 6C
  keratin 77
  keratin 78
  keratin 8
  keratin 80
  keratin 84
  keratin 9
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 15
  KRI1 homolog
  KRR1 small subunit processome component homolog
  La ribonucleoprotein 1, translational regulator
  lactotransferrin
  lamin A/C
  lamin B1
  LAS1 like ribosome biogenesis factor
  leucine rich repeat containing 59
  leucine rich repeat containing G protein-coupled receptor 4
  ligand dependent nuclear receptor interacting factor 1
  lipocalin 1
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  Ly1 antibody reactive
  lysine demethylase 1A
  lysine demethylase 5B
  lysine methyltransferase 2A
  lysine rich nucleolar protein 1
  lysozyme
  MAF bZIP transcription factor G
  mannosidase alpha class 2A member 2
  marker of proliferation Ki-67
  matrin 3
  MDS1 and EVI1 complex locus
  metadherin
  metastasis associated 1
  metastasis associated 1
  metastasis associated 1 family member 2
  metastasis associated 1 family member 3
  methionyl aminopeptidase 2
  methyl-CpG binding domain protein 2
  methyl-CpG binding domain protein 3
  methyl-CpG binding domain protein 3 like 1
  midasin AAA ATPase 1
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 5
  minichromosome maintenance complex component 7
  Mov10 RISC complex RNA helicase
  MRE11 homolog, double strand break repair nuclease
  MRT4 homolog, ribosome maturation factor
  Mtr4 exosome RNA helicase
  mutS homolog 6
  MX dynamin like GTPase 1
  MYB binding protein 1a
  MYB proto-oncogene, transcription factor
  myoglobin
  myosin heavy chain 10
  myosin heavy chain 9
  myosin IB
  myosin light chain 6
  N-acetyltransferase 10
  neurofilament light
  neuroguidin
  NFKB repressing factor
  NGFI-A binding protein 2
  NOC2 like nucleolar associated transcriptional repressor
  NOC3 like DNA replication regulator
  non-POU domain containing octamer binding
  NOP2 nucleolar protein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  NSA2 ribosome biogenesis factor
  nuclear cap binding protein subunit 1
  nuclear cap binding subunit 3
  nuclear mitotic apparatus protein 1
  nuclear receptor coactivator 5
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 4 group A member 1
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleolar and coiled-body phosphoprotein 1
  nucleolar complex associated 4 homolog
  nucleolar protein 10
  nucleolar protein 6
  nucleolar protein 9
  nucleolar protein interacting with the FHA domain of MKI67
  nucleolin
  nucleophosmin 1
  OTU deubiquitinase 6B
  partner of NOB1 homolog
  PAX3 and PAX7 binding protein 1
  PC4 and SFRS1 interacting protein 1
  pericentrin
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 14
  PHD finger protein 20 like 1
  PHD finger protein 6
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleiotrophin
  polo like kinase 4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  poly(U) binding splicing factor 60
  polybromo 1
  polypyrimidine tract binding protein 1
  POZ/BTB and AT hook containing zinc finger 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  programmed cell death 11
  prohibitin
  prohibitin 2
  prolactin induced protein
  proline rich coiled-coil 2C
  proline, glutamate and leucine rich protein 1
  proteasome 26S subunit, non-ATPase 14
  proteasome activator subunit 1
  protein inhibitor of activated STAT 4
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein tyrosine phosphatase receptor type S
  protein-L-isoaspartate (D-aspartate) O-methyltransferase
  proteoglycan 2, pro eosinophil major basic protein
  pumilio RNA binding family member 3
  PWP2 small subunit processome component
  pyrroline-5-carboxylate reductase 2
  RAB10, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAB7A, member RAS oncogene family
  RAD21 cohesin complex component
  RAD51 recombinase
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  receptor for activated C kinase 1
  RecQ like helicase 4
  regulator of G protein signaling 2
  replication factor C subunit 1
  replication factor C subunit 3
  replication timing regulatory factor 1
  reticulophagy regulator family member 2
  retinoic acid induced 1
  REX4 homolog, 3'-5' exonuclease
  ribophorin I
  ribosomal L1 domain containing 1
  ribosomal protein L10
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L14
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L21
  ribosomal protein L22
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L26
  ribosomal protein L27
  ribosomal protein L27a
  ribosomal protein L28
  ribosomal protein L29
  ribosomal protein L3
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L35
  ribosomal protein L36
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S10
  ribosomal protein S11
  ribosomal protein S12
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S17
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S20
  ribosomal protein S23
  ribosomal protein S24
  ribosomal protein S25
  ribosomal protein S27
  ribosomal protein S27 like
  ribosomal protein S27a
  ribosomal protein S28
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal protein SA
  ribosomal RNA processing 1
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 1B
  ribosomal RNA processing 7 homolog A
  ring finger protein 2
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 10
  RNA binding motif protein 14
  RNA binding motif protein 15
  RNA binding motif protein 17
  RNA binding motif protein 25
  RNA binding motif protein 28
  RNA binding motif protein 34
  RNA binding motif protein 39
  RNA binding motif protein 5
  RNA binding motif protein X-linked
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 1
  S100 calcium binding protein A8
  S100 calcium binding protein A9
  SAP domain containing ribonucleoprotein
  SATB homeobox 1
  SATB homeobox 2
  scaffold attachment factor B
  SDA1 domain containing 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine hydroxymethyltransferase 2
  serine protease 1
  SERPINE1 mRNA binding protein 1
  serrate, RNA effector molecule
  signal recognition particle 68
  signal recognition particle 72
  signal recognition particle 72
  SIN3 transcription regulator family member A
  Sin3A associated protein 18
  sirtuin 1
  sirtuin 6
  SKI like proto-oncogene
  small EDRK-rich factor 2
  small G protein signaling modulator 2
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  small nuclear ribonucleoprotein U5 subunit 40
  small ubiquitin like modifier 1
  small ubiquitin like modifier 2
  SNW domain containing 1
  solute carrier family 25 member 3
  solute carrier family 27 member 6
  speckle type BTB/POZ protein
  spectrin beta, non-erythrocytic 1
  spermatid perinuclear RNA binding protein
  spermatogenesis associated serine rich 2
  spermidine/spermine N1-acetyltransferase 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  splicing factor proline and glutamine rich
  splicing factor SWAP
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SR-related CTD associated factor 11
  SRY-box transcription factor 2
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  structure specific recognition protein 1
  SUMO specific peptidase 1
  suprabasin
  SURP and G-patch domain containing 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 6
  tetraspanin 6
  thioredoxin domain containing 9
  THO complex 7
  thymopoietin
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 4
  TNF receptor superfamily member 14
  transcription elongation regulator 1
  transducin beta like 3
  transformer 2 beta homolog
  transthyretin
  tripartite motif containing 25
  tripartite motif containing 28
  troponin T1, slow skeletal type
  TSC22 domain family member 1
  TSR1 ribosome maturation factor
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin beta 4B class IVb
  tubulin beta class I
  tuftelin interacting protein 11
  tumor protein p53
  tumor protein p73
  twist family bHLH transcription factor 1
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin like modifier activating enzyme 3
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 36
  ubiquitin specific peptidase 39
  upstream binding transcription factor
  uroporphyrinogen decarboxylase
  UTP14A small subunit processome component
  vimentin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  WD repeat domain 3
  WD repeat domain 36
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  YAE1 maturation factor of ABCE1
  Y-box binding protein 1
  YLP motif containing 1
  zinc finger and BTB domain containing 5
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type containing 13
  zinc finger CCCH-type containing 18
  zinc finger CCHC-type containing 8
  zinc finger homeobox 4
  zinc finger MYND-type containing 8
  zinc finger protein 146
  zinc finger protein 219
  zinc finger protein 326
  zinc finger protein 512
  zinc finger protein 512B
  zinc finger protein 592
  zinc finger protein 622
  zinc finger protein 687
  zinc finger protein 827
  zinc finger RNA binding protein
  zinc finger with KRAB and SCAN domains 1
  zinc finger with KRAB and SCAN domains 8
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.