GADD45A, growth arrest and DNA damage inducible alpha

GADD45A, growth arrest and DNA damage inducible alpha

• This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

• Gene Synonyms (growth arrest and DNA damage-inducible protein GADD45 alpha, DDIT-1, DNA damage-inducible transcript 1 protein, DNA damage-inducible transcript-1, growth arrest and DNA-damage-inducible 45 alpha, DDIT1, GADD45,)
• NCBI Gene ID: 1647
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A5JUZ3
  UNIPROT ID#>>P24522
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth arrest and DNA damage inducible alpha interacts with:

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  activating signal cointegrator 1 complex subunit 2
  ArfGAP with dual PH domains 1
  aurora kinase A
  BAG cochaperone 6
  BCL2 like 11
  beta-transducin repeat containing E3 ubiquitin protein ligase
  CCR4-NOT transcription complex subunit 9
  chibby family member 2
  C-type lectin domain family 3 member B
  cyclin dependent kinase 11A
  DNA methyltransferase 1
  DnaJ heat shock protein family (Hsp40) member C13
  dynactin subunit 2
  early growth response 1
  ergosterol biosynthesis 28 homolog
  estrogen receptor 1
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 gamma
  family with sequence similarity 83 member D
  ferritin light chain
  fibrillin 3
  G protein subunit beta 2
  GADD45G interacting protein 1
  glutaminyl-tRNA synthetase 1
  glyceraldehyde-3-phosphate dehydrogenase
  growth arrest and DNA damage inducible alpha
  growth arrest and DNA damage inducible beta
  growth arrest and DNA damage inducible gamma
  guanylate binding protein 2
  H1.1 linker histone, cluster member
  H2A clustered histone 16
  H2B clustered histone 21
  H3.4 histone
  H4 clustered histone 14
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  immunoglobin superfamily member 21
  inhibitor of growth family member 4
  jumonji domain containing 1C
  KH-type splicing regulatory protein
  ligand of numb-protein X 2
  LIM domain only 4
  mannan binding lectin serine peptidase 1
  MDM2 proto-oncogene
  mechanistic target of rapamycin kinase
  membrane palmitoylated protein 1
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  midnolin
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase kinase 6
  mitogen-activated protein kinase kinase kinase 4
  nuclear receptor binding protein 1
  nucleobindin 2
  nucleophosmin 1
  parvin gamma
  peroxisome proliferator activated receptor alpha
  peroxisome proliferator activated receptor alpha
  peroxisome proliferator activated receptor gamma
  peroxisome proliferator activator receptor delta
  pleiotrophin
  proliferating cell nuclear antigen
  proteasome 26S subunit, ATPase 3
  protein tyrosine phosphatase receptor type K
  recombination signal binding protein for immunoglobulin kappa J region
  retinoic acid induced 1
  retinoic acid receptor alpha
  retinoid X receptor alpha
  ribosomal protein S2
  ribosomal protein S7
  SH3 domain containing GRB2 like, endophilin B1
  signal transducer and activator of transcription 3
  spectrin beta, non-erythrocytic 4
  spectrin repeat containing nuclear envelope family member 4
  TIA1 cytotoxic granule associated RNA binding protein like 1
  TLE family member 1, transcriptional corepressor
  tumor protein p53
  ubiquitin conjugating enzyme E2 D1
  ubiquitin protein ligase E3 component n-recognin 1
  vimentin
  zinc finger protein 135
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.