FLNB, filamin B

FLNB, filamin B

• This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

• Gene Synonyms (ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin-B, ABP-280 homolog, Larsen syndrome 1 (autosomal dominant), actin binding protein 278, actin-binding-like protein, beta-filamin, filamin B, beta, filamin homolog 1, filamin-3, thyroid autoantigen,)
• NCBI Gene ID: 2317
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75369
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

filamin B interacts with:

• AAR2 splicing factor
  actin, beta
  activating transcription factor 7 interacting protein
  ADP ribosylation factor interacting protein 1
  agrin
  AHNAK nucleoprotein
  anillin actin binding protein
  ankyrin repeat and SOCS box containing 2
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily E member 1
  brain abundant membrane attached signal protein 1
  BRF1 RNA polymerase III transcription initiation factor subunit
  calmodulin-like 3
  CDK5 regulatory subunit associated protein 2
  cell division cycle 73
  coiled-coil domain containing 8
  coronin, actin binding protein 1C
  cullin 7
  DDB1 and CUL4 associated factor 15
  decapping enzyme, scavenger
  dual specificity phosphatase 23
  dynactin subunit 2
  dynactin subunit 3
  elongation factor Tu GTP binding domain containing 2
  fibrillarin
  fibronectin 1
  filamin B
  filamin binding LIM protein 1
  filamin C
  G3BP stress granule assembly factor 1
  glycoprotein Ib platelet subunit alpha
  glypican 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  heat shock protein family B (small) member 1
  heat shock protein family B (small) member 7
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  integrin subunit alpha 4
  integrin subunit beta 1
  integrin subunit beta 3
  integrin subunit beta 3 binding protein
  integrin subunit beta 6
  IQ motif containing GTPase activating protein 1
  ISG15 ubiquitin like modifier
  LEO1 homolog, Paf1/RNA polymerase II complex component
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  magnesium dependent phosphatase 1
  mediator complex subunit 4
  mediator of DNA damage checkpoint 1
  microtubule associated protein 4
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase kinase 1
  mitotic arrest deficient 1 like 1
  MTOR associated protein, eak-7 homolog
  mutL homolog 1
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin IC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 9, non-muscle
  nephrocystin 1
  NMD3 ribosome export adaptor
  nucleophosmin 1
  nucleoporin 210
  nucleoporin 50
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 1
  phosphatase and tensin homolog
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing O1
  presenilin 1
  presenilin 2
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 3
  protein phosphatase 1 catalytic subunit beta
  protein tyrosine phosphatase domain containing 1
  protein tyrosine phosphatase non-receptor type 12
  PTEN induced kinase 1
  Rac family small GTPase 1
  RAD21 cohesin complex component
  RAS like proto-oncogene A
  Ras suppressor protein 1
  ring finger protein 123
  ring finger protein 2
  SEC13 homolog, nuclear pore and COPII coat complex component
  septin 6
  septin 9
  sequestosome 1
  sirtuin 6
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 2
  spindle apparatus coiled-coil protein 1
  SUZ12 polycomb repressive complex 2 subunit
  synaptopodin
  TAR DNA binding protein
  testin LIM domain protein
  testis expressed 101
  thioredoxin like 1
  thyroid stimulating hormone receptor
  transcription factor CP2
  tripartite motif containing 25
  tripartite motif containing 55
  TSC22 domain family member 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 14
  vacuole membrane protein 1
  valosin containing protein
  vascular cell adhesion molecule 1
  VHL binding protein 1
  vir like m6A methyltransferase associated
  Yes1 associated transcriptional regulator
  zinc finger CCCH-type containing 4
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.