NR4A1, nuclear receptor subfamily 4 group A member 1

NR4A1, nuclear receptor subfamily 4 group A member 1

• This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (nuclear receptor subfamily 4 group A member 1, ST-59, TR3 orphan receptor, early response protein NAK1, growth factor-inducible nuclear protein N10, hormone receptor, nerve growth factor IB nuclear receptor variant 1, nuclear hormone receptor NUR/77, orphan nuclear receptor HMR, orphan nuclear receptor TR3, steroid receptor TR3, testicular receptor 3, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3,)
• NCBI Gene ID: 3164
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F5GXF0
  UNIPROT ID#>>A0A024R126
  UNIPROT ID#>>P22736
  UNIPROT ID#>>Q6ZMM6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear receptor subfamily 4 group A member 1 interacts with:

• acyl-CoA dehydrogenase family member 11
  ankyrin repeat and IBR domain containing 1
  ataxin 1
  ATP binding cassette subfamily A member 5
  ATP binding cassette subfamily B member 11
  ATP binding cassette subfamily G member 8
  axin 2
  Bardet-Biedl syndrome 10
  BCL2 like 10
  CD2 associated protein
  checkpoint kinase 2
  chromodomain helicase DNA binding protein 1 like
  cutA divalent cation tolerance homolog
  diablo IAP-binding mitochondrial protein
  DNA polymerase alpha 2, accessory subunit
  DNA topoisomerase II alpha
  exportin 1
  Fas associated factor 1
  FXYD domain containing ion transport regulator 3
  GADD45G interacting protein 1
  glyoxalase domain containing 4
  H4 clustered histone 1
  heat shock protein 90 alpha family class B member 1
  hes family bHLH transcription factor 1
  heterogeneous nuclear ribonucleoprotein A2/B1
  histone deacetylase 6
  homeobox A1
  keratin associated protein 10-1
  keratin associated protein 10-5
  lanosterol synthase
  LON peptidase N-terminal domain and ring finger 1
  lysine acetyltransferase 2B
  mediator complex subunit 1
  mediator complex subunit 31
  metastasis associated 1 family member 2
  midnolin
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase kinase 1
  MYB binding protein 1a
  NAC alpha domain containing
  N-myc downstream regulated 1
  nuclear factor kappa B subunit 1
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 3
  nuclear receptor corepressor 2
  nuclear receptor subfamily 4 group A member 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  peroxiredoxin 4
  peroxiredoxin 6
  peroxisome proliferator activated receptor gamma
  phosphoenolpyruvate carboxykinase 1
  piggyBac transposable element derived 1
  PML nuclear body scaffold
  proline, glutamate and leucine rich protein 1
  pro-platelet basic protein
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 3
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  RB transcriptional corepressor like 1
  reticulon 4
  retinoid X receptor alpha
  retinoid X receptor gamma
  Rho guanine nucleotide exchange factor 10 like
  Rho guanine nucleotide exchange factor 5
  ribosomal protein L7
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase A5
  ribosomal protein S6 kinase A6
  ring finger protein 111
  ring finger protein 4
  ring finger protein, LIM domain interacting
  roundabout guidance receptor 2
  sequestosome 1
  serpin family A member 4
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  signal transducer and activator of transcription 3
  SMAD family member 3
  SMAD family member 7
  suppressor of cytokine signaling 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  TNF receptor associated factor 2
  transcription factor 4
  transmembrane O-mannosyltransferase targeting cadherins 4
  tripartite motif containing 13
  tripartite motif containing 28
  tropomodulin 3
  tubulin beta 4A class IVa
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  vasodilator stimulated phosphoprotein
  von Hippel-Lindau tumor suppressor
  X-ray repair cross complementing 5
  zinc finger protein 331
  zinc finger protein 579

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.