IRF2, interferon regulatory factor 2

IRF2, interferon regulatory factor 2

• IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

• Gene Synonyms (IRF-2, interferon regulatory factor 2,)
• NCBI Gene ID: 3660
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P14316
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interferon regulatory factor 2 interacts with:

• adaptor related protein complex 5 subunit zeta 1
  alanyl-tRNA synthetase 2, mitochondrial
  autophagy related 7
  bromodomain containing 7
  centrosomal protein 170
  charged multivesicular body protein 4B
  coenzyme Q8A
  coiled-coil domain containing 124
  COP9 signalosome subunit 3
  DNA ligase 3
  dpy-30 histone methyltransferase complex regulatory subunit
  FKBP prolyl isomerase 7
  forkhead box K1
  G3BP stress granule assembly factor 1
  galectin 3 binding protein
  glutamine amidotransferase like class 1 domain containing 3A
  GTP binding protein 10
  haloacid dehalogenase like hydrolase domain containing 5
  histone cell cycle regulator
  host cell factor C2
  interferon regulatory factor 2 binding protein 1
  interferon regulatory factor 2 binding protein 2
  interferon regulatory factor 2 binding protein like
  isoleucyl-tRNA synthetase 2, mitochondrial
  keratin 1
  La ribonucleoprotein 4B
  lactate dehydrogenase A
  LEM domain nuclear envelope protein 2
  LSM12 homolog
  lysine acetyltransferase 2B
  lysine methyltransferase 2A
  matrix AAA peptidase interacting protein 1
  MDM2 proto-oncogene
  metadherin
  NADH:ubiquinone oxidoreductase core subunit S2
  nuclear factor kappa B subunit 1
  nucleolin
  nudix hydrolase 19
  polynucleotide kinase 3'-phosphatase
  profilin 1
  proliferation-associated 2G4
  proteasome 26S subunit, ATPase 3
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit beta
  pyrroline-5-carboxylate reductase 2
  RB binding protein 5, histone lysine methyltransferase complex subunit
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 2
  replication protein A1
  replication protein A3
  ribosomal protein L39
  ribosomal protein lateral stalk subunit P1
  signal recognition particle 9
  signal transducer and activator of transcription 1
  single stranded DNA binding protein 1
  Ski2 like RNA helicase
  Spi-1 proto-oncogene
  SPT16 homolog, facilitates chromatin remodeling subunit
  succinate-CoA ligase ADP-forming subunit beta
  tetratricopeptide repeat domain 37
  thymopoietin
  titin
  transcription activation suppressor family member 2
  transcription factor A, mitochondrial
  tripartite motif containing 25
  Tu translation elongation factor, mitochondrial
  ubiquitin protein ligase E3A
  von Willebrand factor A domain containing 8
  VRK serine/threonine kinase 3
  X-ray repair cross complementing 1
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.