BMX, BMX non-receptor tyrosine kinase

BMX, BMX non-receptor tyrosine kinase

• This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

• Gene Synonyms (cytoplasmic tyrosine-protein kinase BMX, BTK-like on X chromosome, Etk/Bmx cytosolic tyrosine kinase, NTK38 tyrosine kinase, bone marrow tyrosine kinase gene in chromosome X protein, epithelial and endothelial tyrosine kinase, ETK, PSCTK2, PSCTK3,)
• NCBI Gene ID: 660
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51813
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BMX non-receptor tyrosine kinase interacts with:

• ariadne RBR E3 ubiquitin protein ligase 2
  BCAR1 scaffold protein, Cas family member
  Bruton tyrosine kinase
  caspase 3
  caveolin 1
  chromosome 12 open reading frame 45
  coiled-coil and C2 domain containing 1B
  COP9 signalosome subunit 8
  cytokine dependent hematopoietic cell linker
  elongator complex protein 1
  epidermal growth factor receptor
  erb-b2 receptor tyrosine kinase 2
  F-box protein 25
  heat shock protein 90 alpha family class A member 1
  IL2 inducible T cell kinase
  kinase insert domain receptor
  kizuna centrosomal protein
  obscurin like cytoskeletal adaptor 1
  p21 (RAC1) activated kinase 1
  programmed cell death 2 like
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 21
  protein tyrosine phosphatase receptor type D
  RAP1A, member of RAS oncogene family
  RUN and FYVE domain containing 1
  RUN and FYVE domain containing 2
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  SRC proto-oncogene, non-receptor tyrosine kinase
  tec protein tyrosine kinase
  TNF receptor superfamily member 1B
  ubiquitin specific peptidase 24
  WD repeat domain 45B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.