BTK, Bruton tyrosine kinase

BTK, Bruton tyrosine kinase

• The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

• Gene Synonyms (tyrosine-protein kinase BTK, B-cell progenitor kinase, Bruton agammaglobulinemia tyrosine kinase, Bruton's tyrosine kinase, agammaglobulinaemia tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, truncated Bruton agammaglobulinemia tyrosine kinase, tyrosine-protein kinase BTK isoform (lacking exon 13 to 17), tyrosine-protein kinase BTK isoform (lacking exon 14), AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA,)
• NCBI Gene ID: 695
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q06187
  UNIPROT ID#>>Q5JY90
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Bruton tyrosine kinase interacts with:

• AFG3 like matrix AAA peptidase subunit 2
  ankyrin repeat domain 54
  AT-rich interaction domain 3A
  aurora kinase A
  B cell linker
  BCL2 like 11
  beclin 1
  Bruton tyrosine kinase
  caveolin 1
  Cbl proto-oncogene
  Cbl proto-oncogene B
  CD19 molecule
  cell division cycle 37, HSP90 cochaperone
  CKLF like MARVEL transmembrane domain containing 3
  Coenzyme A synthase
  coronin 1C
  DEAD-box helicase 3 X-linked
  decapping enzyme, scavenger
  drebrin 1
  dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  eukaryotic translation elongation factor 1 alpha 2
  EWS RNA binding protein 1
  filamin A
  FYN proto-oncogene, Src family tyrosine kinase
  G protein subunit alpha 12
  G protein subunit alpha q
  G protein subunit beta 1
  G protein subunit gamma 2
  general transcription factor IIi
  glyceraldehyde-3-phosphate dehydrogenase
  growth factor receptor bound protein 2
  HCK proto-oncogene, Src family tyrosine kinase
  heat shock protein 90 alpha family class A member 1
  hornerin
  HRas proto-oncogene, GTPase
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  IL2 inducible T cell kinase
  inhibitor of Bruton tyrosine kinase
  interleukin 1 receptor associated kinase 1
  Janus kinase 1
  katanin regulatory subunit B1
  keratin 5
  KH RNA binding domain containing, signal transduction associated 1
  KIT proto-oncogene, receptor tyrosine kinase
  KRAS proto-oncogene, GTPase
  LYN proto-oncogene, Src family tyrosine kinase
  MDM2 proto-oncogene
  mediator complex subunit 28
  membrane palmitoylated protein 7
  mesenchyme homeobox 2
  mitochondrial ribosomal protein S22
  mitogen-activated protein kinase kinase kinase 4
  MYC proto-oncogene, bHLH transcription factor
  MYD88 innate immune signal transduction adaptor
  myelin basic protein
  myosin light chain kinase 2
  NADH:ubiquinone oxidoreductase core subunit S1
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  phosphatidylinositol-4-phosphate 5-kinase type 1 beta
  phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
  phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
  phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  phosphoinositide-3-kinase adaptor protein 1
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  phospholipase C gamma 2
  plasminogen activator, urokinase
  protein kinase C alpha
  protein kinase C beta
  protein kinase C epsilon
  protein kinase C theta
  protein kinase C zeta
  protein kinase D1
  RELA proto-oncogene, NF-kB subunit
  Rho GTPase activating protein 17
  ribosomal protein S3
  ribosomal protein S6 kinase B1
  ribosomal protein S6 kinase B2
  SH2B adaptor protein 2
  SH3 domain binding protein 5
  signal transducer and activator of transcription 5A
  SMAD specific E3 ubiquitin protein ligase 1
  spectrin alpha, erythrocytic 1
  spleen associated tyrosine kinase
  splicing factor proline and glutamine rich
  tec protein tyrosine kinase
  tetratricopeptide repeat domain 9C
  TIR domain containing adaptor protein
  TNF receptor superfamily member 10a
  toll like receptor 4
  toll like receptor 6
  toll like receptor 8
  toll like receptor 9
  tubulin alpha 4a
  tubulin beta 4B class IVb
  tumor protein p53
  twinfilin actin binding protein 1
  vav guanine nucleotide exchange factor 1
  WASP actin nucleation promoting factor
  WASP family member 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.