CD74, CD74 molecule

CD74, CD74 molecule

• The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

• Gene Synonyms (HLA class II histocompatibility antigen gamma chain, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain, gamma chain of class II antigens, DHLAG, HLADG, II, Ia-GAMMA, p33,)
• NCBI Gene ID: 972
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04233
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD74 molecule interacts with:

• activating signal cointegrator 1 complex subunit 1
  activating signal cointegrator 1 complex subunit 3
  adaptor related protein complex 3 subunit delta 1
  A-kinase anchoring protein 8
  ankyrin repeat domain 28
  Bet1 golgi vesicular membrane trafficking protein
  cathepsin F
  cathepsin L
  CD74 molecule
  chromatin assembly factor 1 subunit B
  chromosome 14 open reading frame 180
  CKLF like MARVEL transmembrane domain containing 7
  claudin 19
  COPI coat complex subunit alpha
  COPI coat complex subunit beta 1
  COPI coat complex subunit beta 2
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  C-type lectin domain containing 7A
  cullin 7
  DExD/H-box helicase 60
  diacylglycerol kinase epsilon
  DnaJ heat shock protein family (Hsp40) member B11
  DnaJ heat shock protein family (Hsp40) member B12
  epididymal protein 3B
  ergosterol biosynthesis 28 homolog
  eukaryotic translation initiation factor 1
  eukaryotic translation initiation factor 2 subunit alpha
  eukaryotic translation initiation factor 2 subunit gamma
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit epsilon
  eukaryotic translation initiation factor 2B subunit gamma
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit E
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3 subunit G
  eukaryotic translation initiation factor 3 subunit H
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 3 subunit J
  eukaryotic translation initiation factor 3 subunit K
  eukaryotic translation initiation factor 3 subunit L
  eukaryotic translation initiation factor 3 subunit M
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4A1
  farnesyl-diphosphate farnesyltransferase 1
  FKBP prolyl isomerase 8
  FXYD domain containing ion transport regulator 6
  gem nuclear organelle associated protein 4
  general transcription factor IIi
  general transcription factor IIIC subunit 1
  glucosidase II alpha subunit
  GRAM domain containing 1A
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heme oxygenase 2
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  importin 13
  interferon induced transmembrane protein 3
  IQ motif containing GTPase activating protein 2
  karyopherin subunit beta 1
  keratin 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  listerin E3 ubiquitin protein ligase 1
  lysophosphatidic acid receptor 3
  macrophage migration inhibitory factor
  major histocompatibility complex, class II, DM alpha
  major histocompatibility complex, class II, DM beta
  major histocompatibility complex, class II, DP alpha 1
  major histocompatibility complex, class II, DP beta 1
  major histocompatibility complex, class II, DQ alpha 1
  major histocompatibility complex, class II, DQ beta 1
  major histocompatibility complex, class II, DR alpha
  mechanistic target of rapamycin kinase
  microtubule associated protein 1B
  mitogen-activated protein kinase kinase kinase 1
  non-SMC condensin I complex subunit D2
  non-SMC condensin I complex subunit H
  non-SMC condensin II complex subunit D3
  oxysterol binding protein like 8
  patched 1
  PDGFA associated protein 1
  pepsinogen A4
  phospholipid phosphatase 4
  progesterone receptor membrane component 1
  progesterone receptor membrane component 2
  programmed cell death 4
  prohibitin
  proliferating cell nuclear antigen
  proline rich coiled-coil 2A
  proline rich coiled-coil 2B
  proline rich coiled-coil 2C
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 6
  protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 3
  proteolipid protein 1
  ras homolog family member T2
  receptor transporter protein 2
  reticulocalbin 1
  RNA polymerase II, I and III subunit E
  RNA polymerase III subunit A
  RNA polymerase III subunit B
  RWD domain containing 1
  SEC22 homolog A, vesicle trafficking protein
  signal recognition particle 9
  small integral membrane protein 1 (Vel blood group)
  small nuclear ribonucleoprotein polypeptide E
  solute carrier family 35 member B1
  sphingosine-1-phosphate lyase 1
  stress associated endoplasmic reticulum protein 1
  testis expressed 11
  tight junction protein 2
  transforming growth factor beta regulator 4
  transmembrane 4 L six family member 20
  transmembrane protein 120B
  transmembrane protein 243
  transmembrane protein 254
  transmembrane protein 60
  transmembrane protein 97
  tripeptidyl peptidase 2
  tubulin alpha 1a
  tubulin alpha 1c
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3C
  uroplakin 2
  voltage dependent anion channel 1
  von Willebrand factor A domain containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.