GTF2I, general transcription factor IIi

GTF2I, general transcription factor IIi

• This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]

• Gene Synonyms (general transcription factor II-I, BTK-associated protein, 135kD, Bruton tyrosine kinase-associated protein 135, SRF-Phox1-interacting protein, Williams-Beuren syndrome chromosome region 6, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6,)
• NCBI Gene ID: 2969
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78347
  UNIPROT ID#>>X5D939
  UNIPROT ID#>>X5D2J9
  UNIPROT ID#>>X5DNP5
  UNIPROT ID#>>A8K9W7
  UNIPROT ID#>>Q499G6
  UNIPROT ID#>>X5DR09
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

general transcription factor IIi interacts with:

• AAR2 splicing factor
  activating transcription factor 6
  adaptor related protein complex 4 subunit sigma 1
  ataxin 3
  BCL2 like 11
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  cancer/testis antigen 1A
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  checkpoint kinase 2
  chromatin assembly factor 1 subunit A
  chromobox 2
  chromobox 4
  CTP synthase 2
  cullin 3
  DNA methyltransferase 3 like
  dpy-30 histone methyltransferase complex regulatory subunit
  dual specificity phosphatase 15
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  extra spindle pole bodies 1, separase
  F-box and WD repeat domain containing 11
  F-box protein 6
  forkhead box A1
  galectin 1
  galectin 3
  general transcription factor IIi
  GRIP and coiled-coil domain containing 1
  GTF2I repeat domain containing 2B
  H2A clustered histone 4
  H2B clustered histone 3
  H3 clustered histone 6
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein L
  HEXIM P-TEFb complex subunit 1
  histone cell cycle regulator
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  hypoxia inducible factor 1 subunit alpha
  inositol polyphosphate phosphatase like 1
  integrin alpha FG-GAP repeat containing 1
  Janus kinase 2
  La ribonucleoprotein 7, transcriptional regulator
  LIM domain and actin binding 1
  LSM8 homolog, U6 small nuclear RNA associated
  lysine demethylase 1A
  lysine methyltransferase 5C
  mab-21 like 2
  macroH2A.1 histone
  MAD2 mitotic arrest deficient-like 2
  MAGE family member A1
  MAGE family member A3
  matrin 3
  MDM2 proto-oncogene
  methylphosphate capping enzyme
  methyltransferase like 1
  methyltransferase like 3
  microtubule associated scaffold protein 2
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase kinase kinase 3
  mitotic arrest deficient 2 like 2
  MYC proto-oncogene, bHLH transcription factor
  myotubularin related protein 7
  neurotrophic receptor tyrosine kinase 1
  nuclear factor kappa B subunit 1
  nuclear factor kappa B subunit 2
  nuclear factor of activated T cells 2 interacting protein
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nucleobindin 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  paired related homeobox 1
  palmitoyl-protein thioesterase 1
  peroxisome proliferator activated receptor gamma
  PHD finger protein 21A
  phosphatase and actin regulator 3
  phosphoribosyl pyrophosphate synthetase 2
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POU class 2 homeobox associating factor 1
  praja ring finger ubiquitin ligase 1
  pre-mRNA processing factor 8
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 2
  protein kinase cGMP-dependent 1
  protein kinase, DNA-activated, catalytic subunit
  protein prenyltransferase alpha subunit repeat containing 1
  protein tyrosine phosphatase 4A3
  pyrimidinergic receptor P2Y6
  pyroglutamyl-peptidase I
  pyruvate dehydrogenase E1 subunit alpha 1
  RAB27A, member RAS oncogene family
  RAD23 homolog B, nucleotide excision repair protein
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  retinoic acid receptor alpha
  ribosomal protein L28
  ribosomal protein S6 kinase B2
  ring finger protein 2
  RIO kinase 1
  RNA polymerase II subunit A
  sclerostin
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 9
  serine/arginine repetitive matrix 2
  serine/threonine/tyrosine interacting protein
  serum response factor
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  sirtuin 6
  sirtuin 7
  SLU7 homolog, splicing factor
  SMAD family member 2
  small nuclear ribonucleoprotein polypeptide N
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  SUZ12 polycomb repressive complex 2 subunit
  syntaxin 7
  TATA-box binding protein associated factor 15
  t-complex 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  thioredoxin interacting protein
  tigger transposable element derived 6
  TNF receptor associated factor 6
  toll like receptor 9
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  transcription factor AP-4
  transcription factor CP2
  tripartite motif containing 54
  tRNA methyltransferase 1 like
  tryptophanyl-tRNA synthetase 1
  TUB like protein 3
  tubulin gamma 1
  tubulin, alpha 3A
  tumor protein p53
  ubiquilin 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 37
  ubiquitin specific peptidase 7
  upstream transcription factor 1
  vir like m6A methyltransferase associated
  VPS11 core subunit of CORVET and HOPS complexes
  Yes1 associated transcriptional regulator
  YY1 transcription factor
  zinc finger and BTB domain containing 17
  zinc finger and BTB domain containing 7A
  zinc finger containing ubiquitin peptidase 1
  zinc finger MYM-type containing 2
  zinc finger MYM-type containing 3
  zinc finger protein 428

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.