EPS15, epidermal growth factor receptor pathway substrate 15

EPS15, epidermal growth factor receptor pathway substrate 15

• This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

• Gene Synonyms (AF-1P, AF1P, MLLT5, epidermal growth factor receptor substrate 15, ALL1 fused gene from chromosome 1, protein AF-1p,)
• NCBI Gene ID: 2060
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z240
  UNIPROT ID#>>P42566
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

epidermal growth factor receptor pathway substrate 15 interacts with:

• 3-oxoacid CoA-transferase 1
  actin, beta
  anillin actin binding protein
  ArfGAP with FG repeats 1
  ArfGAP with FG repeats 2
  aurora kinase A
  BMP2 inducible kinase
  calmodulin-like 3
  cell division cycle 40
  chaperonin containing TCP1 subunit 3
  clathrin interactor 1
  coiled-coil domain containing 172
  coronin 7
  cyclin G associated kinase
  DDB1 and CUL4 associated factor 1
  disabled 2, mitogen-responsive phosphoprotein
  epidermal growth factor receptor pathway substrate 15
  epsin 1
  epsin 2
  epsin 3
  exportin 1
  FCH and mu domain containing endocytic adaptor 1
  FCH and mu domain containing endocytic adaptor 2
  FCH domain only 2
  fibronectin 1
  filamin A
  filamin, beta
  flotillin 1
  G2 and S-phase expressed 1
  gap junction protein alpha 1
  growth factor receptor bound protein 2
  H4 histone 16
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein L
  integrin subunit alpha 4
  intersectin 1
  intersectin 2
  IQ motif containing GTPase activating protein 1
  keratin 1
  keratin 10
  keratin 14
  keratin 16
  keratin 17
  keratin 2
  keratin 3
  keratin 32
  keratin 33B
  keratin 34
  keratin 35
  keratin 36
  keratin 37
  keratin 38
  keratin 4
  keratin 5
  keratin 6A
  keratin 73
  keratin 75
  keratin 79
  keratin 82
  keratin 83
  keratin 85
  keratin 86
  keratin 9
  keratin associated protein 9-3
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  lipolysis stimulated lipoprotein receptor
  lysosomal protein transmembrane 5
  melatonin receptor 1A
  methylcrotonoyl-CoA carboxylase 2
  microtubule associated protein 4
  microtubule associated protein RP/EB family member 1
  mindbomb E3 ubiquitin protein ligase 1
  MOB family member 4, phocein
  myosin heavy chain 9
  myosin IC
  myosin VI
  myosin XIX
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  NECAP endocytosis associated 1
  NECAP endocytosis associated 2
  NEDD4 E3 ubiquitin protein ligase
  neurotrophic receptor tyrosine kinase 1
  non-POU domain containing octamer binding
  NUMB endocytic adaptor protein
  NUMB endocytic adaptor protein
  NUMB like endocytic adaptor protein
  occludin
  optineurin
  parkin RBR E3 ubiquitin protein ligase
  PDZ and LIM domain 7
  peroxiredoxin 1
  phosphatidylinositol binding clathrin assembly protein
  polo like kinase 1
  propionyl-CoA carboxylase subunit beta
  protein phosphatase 1 catalytic subunit beta
  RAB, member RAS oncogene family like 6
  RAB11 family interacting protein 2
  RAD23 homolog A, nucleotide excision repair protein
  RALBP1 associated Eps domain containing 2
  ring finger protein 11
  ring finger protein 26
  RUN domain containing 3A
  Sec24 related gene family, member C (S. cerevisiae)
  secretory carrier membrane protein 1
  serine/threonine kinase 40
  SH3 domain binding protein 4
  SH3GL interacting endocytic adaptor 1
  signal transducing adaptor molecule 2
  solute carrier family 25 member 41
  solute carrier family 6 member 3
  spartin
  SPC25 component of NDC80 kinetochore complex
  speckle type BTB/POZ protein like
  STAM binding protein
  STAM binding protein like 1
  stonin 2
  synaptojanin 1
  synaptopodin
  synaptosome associated protein 91
  TNF receptor associated factor 2
  transcription factor AP-2 alpha
  transforming growth factor beta 1
  transmembrane protein 17
  tropomyosin 1, alpha
  tubulin beta class I
  ubiquilin 1
  ubiquilin 2
  ubiquitin B
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 H
  ubiquitin specific peptidase 8
  vascular cell adhesion molecule 1
  V-set and immunoglobulin domain containing 8
  ZW10 interactor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.