GTF2B, general transcription factor IIB

GTF2B, general transcription factor IIB

• This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription initiation factor IIB, RNA polymerase II transcription factor IIB, S300-II, general transcription factor TFIIB, TF2B, TFIIB,)
• NCBI Gene ID: 2959
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q00403
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

general transcription factor IIB interacts with:

• 3-hydroxy-3-methylglutaryl-CoA lyase
  3-oxoacyl-ACP synthase, mitochondrial
  alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
  class II major histocompatibility complex transactivator
  CTD phosphatase subunit 1
  DEP domain containing 7
  DR1 associated protein 1
  elongation factor Tu GTP binding domain containing 2
  F-box protein 25
  general transcription factor IIB
  general transcription factor IIE subunit 1
  general transcription factor IIE subunit 2
  general transcription factor IIF subunit 1
  general transcription factor IIF subunit 2
  general transcription factor IIH subunit 4
  golgin A6 family like 9
  heat shock transcription factor 1
  hepatocyte nuclear factor 4 alpha
  IKAROS family zinc finger 1
  Janus kinase 3
  joining chain of multimeric IgA and IgM
  Jun proto-oncogene, AP-1 transcription factor subunit
  listerin E3 ubiquitin protein ligase 1
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
  mediator complex subunit 21
  mediator complex subunit 4
  methyl-CpG binding protein 2
  minichromosome maintenance complex component 2
  mohawk homeobox
  mucin 7, secreted
  NOP2/Sun RNA methyltransferase 2
  nuclear receptor coactivator 1
  nuclear receptor coactivator 3
  nuclear receptor coactivator 4
  nuclear receptor corepressor 1
  nuclear receptor subfamily 1 group D member 2
  nuclear receptor subfamily 2 group F member 1
  nuclear RNA export factor 1
  nucleolar and coiled-body phosphoprotein 1
  nucleosome assembly protein 1 like 1
  plakophilin 2
  pleckstrin homology domain containing A4
  polymeric immunoglobulin receptor
  POU class 3 homeobox 2
  pre-mRNA processing factor 18
  proline rich protein BstNI subfamily 1
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 5
  RE1 silencing transcription factor
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 5
  ribosomal protein L10
  RNA polymerase II subunit A
  RNA polymerase II subunit C
  RNA polymerase II subunit G
  RNA polymerase II subunit J
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit F
  RNA polymerase II, I and III subunit H
  RNA polymerase III subunit A
  Sin3A associated protein 25
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 22 member 2
  steroid receptor RNA activator 1
  TATA-box binding protein
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 9
  TATA-box binding protein like 1
  thyroid hormone receptor alpha
  TNFAIP3 interacting protein 1
  transcription elongation factor A1
  transcription elongation factor A2
  translocation associated membrane protein 2
  vitamin D receptor
  WW domain containing E3 ubiquitin protein ligase 2
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.