HDGF, heparin binding growth factor

HDGF, heparin binding growth factor

• This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

• Gene Synonyms (hepatoma-derived growth factor, epididymis secretory sperm binding protein, hepatoma derived growth factor, high mobility group protein 1-like 2, HMG1L2,)
• NCBI Gene ID: 3068
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51858
  UNIPROT ID#>>B7Z958
  UNIPROT ID#>>A8K8G0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heparin binding growth factor interacts with:

• AAR2 splicing factor
  agrin
  Aly/REF export factor
  ankyrin repeat and SOCS box containing 6
  ATPase family AAA domain containing 3A
  biogenesis of ribosomes BRX1
  BMS1 ribosome biogenesis factor
  bromodomain adjacent to zinc finger domain 1B
  BUB3 mitotic checkpoint protein
  chromobox 3
  chromosome 7 open reading frame 26
  chromosome 7 open reading frame 50
  chromosome 8 open reading frame 33
  ciliary rootlet coiled-coil, rootletin
  copine 2
  cytoskeleton associated protein 4
  DEAD-box helicase 17
  DEAD-box helicase 47
  DEK proto-oncogene
  developmentally regulated GTP binding protein 1
  DExD-box helicase 21
  DExD-box helicase 50
  DExH-box helicase 30
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DNA polymerase delta interacting protein 3
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member A1
  EBNA1 binding protein 2
  EGF like domain multiple 6
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2 subunit beta
  eukaryotic translation initiation factor 5B
  exosome component 10
  exosome component 2
  exosome component 3
  exosome component 6
  forkhead box A1
  G protein nucleolar 3
  glutamate rich WD repeat containing 1
  GTP binding protein 1
  H1.10 linker histone
  H2B clustered histone 10
  H2B clustered histone 12
  H2B clustered histone 21
  H2B clustered histone 4
  H2B clustered histone 6
  H2B clustered histone 7
  H2B clustered histone 8
  H3 clustered histone 1
  H3 clustered histone 10
  H3 clustered histone 11
  H3 clustered histone 12
  H3 clustered histone 2
  H3 clustered histone 3
  H3 clustered histone 4
  H3 clustered histone 6
  H3 clustered histone 7
  H3 clustered histone 8
  H4 clustered histone 1
  H4 clustered histone 11
  H4 clustered histone 12
  H4 clustered histone 13
  H4 clustered histone 14
  H4 clustered histone 15
  H4 clustered histone 2
  H4 clustered histone 3
  H4 clustered histone 4
  H4 clustered histone 5
  H4 clustered histone 6
  H4 clustered histone 8
  H4 clustered histone 9
  H4 histone 16
  heat shock protein family A (Hsp70) member 9
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein U
  high mobility group AT-hook 2
  high mobility group nucleosome binding domain 1
  integrator complex subunit 10
  integrator complex subunit 13
  integrator complex subunit 14
  Jun proto-oncogene, AP-1 transcription factor subunit
  karyopherin subunit alpha 2
  keratin 1
  keratin 10
  keratin 2
  kinesin family member 2A
  lamin A/C
  leucine rich repeat containing 59
  Ly1 antibody reactive
  lysine acetyltransferase 5
  macroH2A.1 histone
  macroH2A.2 histone
  MAGE family member B2
  MCTS1 re-initiation and release factor
  microtubule associated protein 4
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S27
  Mov10 RISC complex RNA helicase
  MRT4 homolog, ribosome maturation factor
  MYB binding protein 1a
  nascent polypeptide associated complex subunit alpha
  neurotrophic receptor tyrosine kinase 1
  N-methylpurine DNA glycosylase
  NOP2 nucleolar protein
  nuclear distribution C, dynein complex regulator
  nuclear receptor binding SET domain protein 2
  nuclear RNA export factor 1
  nucleolin
  Obg like ATPase 1
  parkin RBR E3 ubiquitin protein ligase
  PC4 and SFRS1 interacting protein 1
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 6
  phenylalanyl-tRNA synthetase subunit beta
  PIH1 domain containing 1
  plastin 3
  pleckstrin homology domain containing A4
  proteasome activator subunit 3
  protein arginine methyltransferase 5
  protein kinase, DNA-activated, catalytic subunit
  PWP2 small subunit processome component
  RAN, member RAS oncogene family
  RB binding protein 4, chromatin remodeling factor
  regulator of chromosome condensation 2
  replication factor C subunit 1
  replication factor C subunit 3
  replication factor C subunit 4
  replication factor C subunit 5
  replication protein A1
  ribonuclease P/MRP subunit p38
  ribosomal L1 domain containing 1
  ribosomal protein L10
  ribosomal protein L17
  ribosomal protein L19
  ribosomal protein L22
  ribosomal protein L32
  ribosomal protein L34
  ribosomal protein L35
  ribosomal protein L35a
  ribosomal protein S11
  ribosomal protein S15a
  ribosomal protein S23
  ribosomal RNA processing 1B
  RNA binding motif protein 39
  RNA binding motif protein X-linked
  RNA polymerase mitochondrial
  RNA terminal phosphate cyclase like 1
  RuvB like AAA ATPase 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 2
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 7
  serine protease 3
  SH2 domain containing 4A
  signal recognition particle 68
  signal recognition particle 72
  signal sequence receptor subunit 1
  SMAD family member 4
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein polypeptide F
  small RNA binding exonuclease protection factor La
  solute carrier family 25 member 3
  SPT16 homolog, facilitates chromatin remodeling subunit
  SRSF protein kinase 1
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 3
  structure specific recognition protein 1
  SUB1 regulator of transcription
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  THO complex 3
  thymopoietin
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  TSR1 ribosome maturation factor
  tumor protein, translationally-controlled 1
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin protein ligase E3 component n-recognin 7
  WD repeat domain 36
  WD repeat domain 5
  X-box binding protein 1
  X-ray repair cross complementing 5
  YY1 associated factor 2
  zinc finger CCCH-type containing, antiviral 1
  zinc finger RANBP2-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.