ILK, integrin linked kinase

ILK, integrin linked kinase

• This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

• Gene Synonyms (integrin-linked protein kinase, 59 kDa serine/threonine-protein kinase, epididymis secretory protein Li 28, integrin-linked kinase-2, HEL-S-28, ILK-1, ILK-2, P59, p59ILK,)
• NCBI Gene ID: 3611
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13418
  UNIPROT ID#>>V9HWF0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin linked kinase interacts with:

• 3-phosphoinositide dependent protein kinase 1
  acid phosphatase 6, lysophosphatidic
  activity dependent neuroprotector homeobox
  ADAM metallopeptidase domain 12
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  Aly/REF export factor
  apoptosis inducing factor mitochondria associated 1
  ATP binding cassette subfamily E member 1
  ATP binding cassette subfamily F member 2
  ATP synthase membrane subunit DAPIT
  ATPase family AAA domain containing 3A
  BAG cochaperone 2
  bromodomain containing 7
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase
  CDV3 homolog
  cell cycle associated protein 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  CLN6 transmembrane ER protein
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 47
  COP9 signalosome subunit 5
  COPI coat complex subunit beta 2
  COPI coat complex subunit gamma 1
  cullin 1
  cullin 3
  cullin 5
  cyclic GMP-AMP synthase
  cyclin and CBS domain divalent metal cation transport mediator 3
  DEAD-box helicase 17
  DEAH-box helicase 36
  DExD-box helicase 21
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B11
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  dynein axonemal assembly factor 5
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  elongin C
  EMAP like 4
  exportin 1
  FA complementation group I
  Fas associated factor 1
  F-box protein 6
  fermitin family member 1
  fermitin family member 2
  fermitin family member 3
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 4
  HAUS augmin like complex subunit 5
  HCLS1 associated protein X-1
  HEAT repeat containing 1
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein M
  hypoxia inducible factor 1 subunit alpha inhibitor
  ILK associated serine/threonine phosphatase
  ilvB acetolactate synthase like
  importin 7
  insulin like growth factor 2 mRNA binding protein 1
  insulin receptor substrate 4
  integrin linked kinase
  integrin subunit alpha 5
  integrin subunit alpha V
  integrin subunit beta 1
  integrin subunit beta 2
  integrin subunit beta 3
  integrin subunit beta 4
  intercellular adhesion molecule 5
  karyopherin subunit beta 1
  keratin 73
  kinesin family member 2A
  lamin A/C
  lamin B1
  LIM and SH3 protein 1
  LIM zinc finger domain containing 1
  LIM zinc finger domain containing 2
  lon peptidase 1, mitochondrial
  LSM11, U7 small nuclear RNA associated
  lysophosphatidylcholine acyltransferase 1
  MAGE family member D1
  megakaryocyte-associated tyrosine kinase
  methionyl-tRNA synthetase 1
  mitochondrial intermediate peptidase
  mitochondrial ribosomal protein L44
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Mov10 RISC complex RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  myelin basic protein
  myosin ID
  myotubularin 1
  NADH:ubiquinone oxidoreductase core subunit S3
  natriuretic peptide receptor 2
  NCK adaptor protein 2
  NDUFA4 mitochondrial complex associated
  NOC2 like nucleolar associated transcriptional repressor
  notch receptor 1
  NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  nuclear RNA export factor 1
  nucleosome assembly protein 1 like 1
  OTU deubiquitinase 4
  OXA1L mitochondrial inner membrane protein
  parvin alpha
  parvin beta
  parvin gamma
  patatin like phospholipase domain containing 6
  paxillin
  PDZ and LIM domain 5
  periostin
  phosphatidylinositol binding clathrin assembly protein
  phosphofructokinase, platelet
  phosphoribosyl pyrophosphate amidotransferase
  phosphoribosyl pyrophosphate synthetase associated protein 1
  plakophilin 2
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  poly(U) binding splicing factor 60
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 regulatory subunit 12A
  protein phosphatase 6 catalytic subunit
  protein tyrosine phosphatase non-receptor type 11
  Raf-1 proto-oncogene, serine/threonine kinase
  RAN binding protein 9
  RAN, member RAS oncogene family
  ras homolog family member T1
  ras homolog family member T2
  Ras suppressor protein 1
  RB binding protein 7, chromatin remodeling factor
  receptor interacting serine/threonine kinase 4
  reticulocalbin 1
  reticulocalbin 2
  ribophorin I
  ribosomal protein L13
  ribosomal RNA processing 8
  ring finger protein 19A, RBR E3 ubiquitin protein ligase
  RNA polymerase II subunit B
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  S100 calcium binding protein A9
  SEC61 translocon subunit alpha 1
  serine hydroxymethyltransferase 2
  serine peptidase inhibitor, Kunitz type 2
  serine/arginine repetitive matrix 2
  serpin family A member 4
  SH2B adaptor protein 3
  SHC adaptor protein 1
  shroom family member 3
  sideroflexin 3
  signal regulatory protein alpha
  signal sequence receptor subunit 1
  signal sequence receptor subunit 4
  single stranded DNA binding protein 1
  small nuclear ribonucleoprotein U11/U12 subunit 35
  SNW domain containing 1
  solute carrier family 12 member 2
  solute carrier family 16 member 1
  solute carrier family 2 member 1
  solute carrier family 25 member 1
  solute carrier family 25 member 13
  solute carrier family 25 member 22
  SRY-box transcription factor 2
  STIP1 homology and U-box containing protein 1
  stromal cell derived factor 4
  syndecan binding protein
  synthesis of cytochrome C oxidase 2
  t-complex 1
  thymosin beta 4 X-linked
  TraB domain containing
  TRAF-type zinc finger domain containing 1
  trans-2,3-enoyl-CoA reductase
  translocase of inner mitochondrial membrane 50
  translocase of outer mitochondrial membrane 22
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  tubulin alpha 4a
  tubulin beta 2A class IIa
  tubulin beta 4A class IVa
  tubulin beta 6 class V
  tumor protein p63
  twinfilin actin binding protein 2
  ubiquitin associated protein 2 like
  UDP-glucose pyrophosphorylase 2
  uridine-cytidine kinase 2
  vitamin K epoxide reductase complex subunit 1
  VRK serine/threonine kinase 2
  WD repeat domain 6
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 133
  zinc finger protein 205
  zinc finger protein 568
  zinc finger protein 579
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.