JAK2, Janus kinase 2

JAK2, Janus kinase 2

• This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (JTK10, THCYT3, tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase),)
• NCBI Gene ID: 3717
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60674
  UNIPROT ID#>>B4DYV1
  UNIPROT ID#>>A8K910
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Janus kinase 2 interacts with:

• ADP ribosylation factor like GTPase 11
  ankyrin repeat and SOCS box containing 2
  C-C motif chemokine receptor 2
  cullin 4A
  cullin 4B
  C-X-C motif chemokine receptor 4
  cytokine receptor like factor 2
  deltex E3 ubiquitin ligase 3L
  DnaJ heat shock protein family (Hsp40) member A3
  elongator acetyltransferase complex subunit 2
  golgi phosphoprotein 3
  H3 clustered histone 14
  H3.4 histone
  heat shock transcription factor Y-linked 1
  hes family bHLH transcription factor 5
  histone deacetylase 6
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin receptor substrate 2
  interferon gamma receptor 1
  interleukin 23 receptor
  Janus kinase 2
  Janus kinase 3
  karyopherin subunit beta 1
  KIT proto-oncogene, receptor tyrosine kinase
  LDOC1 regulator of NFKB signaling
  leptin receptor
  ligand of numb-protein X 1
  LIM domain only 4
  LYN proto-oncogene, Src family tyrosine kinase
  macrophage stimulating 1 receptor
  midkine
  mitogen-activated protein kinase kinase kinase 5
  MPL proto-oncogene, thrombopoietin receptor
  NFKB inhibitor alpha
  nucleosome assembly protein 1 like 1
  oncostatin M receptor
  peptidylprolyl isomerase A
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  platelet activating factor receptor
  platelet derived growth factor receptor beta
  poly(ADP-ribose) polymerase family member 9
  polycystin 1, transient receptor potential channel interacting
  prolactin receptor
  protein arginine methyltransferase 5
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 2 scaffold subunit Abeta
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 12
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type C
  Raf-1 proto-oncogene, serine/threonine kinase
  reticulocalbin 1
  ring finger protein 123
  RNA binding motif protein X-linked
  SH2B adaptor protein 1
  SH2B adaptor protein 2
  SHC adaptor protein 1
  signal regulatory protein alpha
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 2
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  signal transducing adaptor family member 2
  signal transducing adaptor molecule
  signal transducing adaptor molecule 2
  solute carrier family 2 member 1
  S-phase kinase associated protein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  tec protein tyrosine kinase
  thyroid stimulating hormone receptor
  TNF receptor associated factor 6
  TNF receptor superfamily member 1A
  TUB bipartite transcription factor
  ubiquitin associated and SH3 domain containing B
  upstream binding protein 1
  valosin containing protein
  vav guanine nucleotide exchange factor 1
  von Hippel-Lindau tumor suppressor
  YES proto-oncogene 1, Src family tyrosine kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.