HDAC1, histone deacetylase 1

HDAC1, histone deacetylase 1

• Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (histone deacetylase 1, reduced potassium dependency, yeast homolog-like 1, GON-10, HD1, KDAC1, RPD3, RPD3L1,)
• NCBI Gene ID: 3065
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13547
  UNIPROT ID#>>Q6IT96
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histone deacetylase 1 interacts with:

• actin related protein 8
  activating signal cointegrator 1 complex subunit 2
  activity dependent neuroprotector homeobox
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  AF4/FMR2 family member 1
  ankyrin repeat domain 13B
  arginine glutamic acid dipeptide (RE) repeats
  AT-rich interaction domain 4A
  AT-rich interaction domain 4B
  AT-rich interaction domain 5B
  autophagy related 16 like 1
  BAF chromatin remodeling complex subunit BCL11A
  BAF chromatin remodeling complex subunit BCL11B
  BAF nuclear assembly factor 1
  BAH domain and coiled-coil containing 1
  basic helix-loop-helix family member e40
  basic helix-loop-helix family member e41
  BBX high mobility group box domain containing
  BCAS3 microtubule associated cell migration factor
  BCL6 corepressor
  BCL6B transcription repressor
  BEN domain containing 3
  BRCA1/BRCA2-containing complex subunit 3
  BRMS1 like transcriptional repressor
  BRMS1 transcriptional repressor and anoikis regulator
  bromo adjacent homology domain containing 1
  bromodomain adjacent to zinc finger domain 2A
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  BTG3 associated nuclear protein
  BUB3 mitotic checkpoint protein
  calcineurin binding protein 1
  carnosine N-methyltransferase 1
  caspase 8 associated protein 2
  CDC42 binding protein kinase alpha
  CDK2 (cyclin-dependent kinase 2)-associated protein 1
  cellular communication network factor 5
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  checkpoint with forkhead and ring finger domains
  chromobox 1
  chromobox 3
  chromobox 5
  chromodomain helicase DNA binding protein 5
  chromodomain Y like
  chromosome 16 open reading frame 87
  chromosome 2 open reading frame 69
  chromosome 22 open reading frame 31
  class II major histocompatibility complex transactivator
  coiled-coil domain containing 6
  coiled-coil domain containing 71
  component of oligomeric golgi complex 4
  cullin 4A
  cullin 4B
  cyclin dependent kinase 2 associated protein 1
  cyclin dependent kinase 20
  cyclin dependent kinase 5 regulatory subunit 1
  cyclin L2
  cytochrome b reductase 1
  DAZ interacting zinc finger protein 3
  DDB1 and CUL4 associated factor 1
  DEAD-box helicase 17
  deoxynucleotidyltransferase terminal interacting protein 1
  desumoylating isopeptidase 1
  dishevelled binding antagonist of beta catenin 1
  DNA methyltransferase (cytosine-5) 1
  DNA methyltransferase 1 associated protein 1
  DNA methyltransferase 3 like
  DNA polymerase delta 3, accessory subunit
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  DnaJ heat shock protein family (Hsp40) member C6
  E1A binding protein p400
  EF-hand calcium binding domain 6
  embryonic ectoderm development
  EMSY transcriptional repressor, BRCA2 interacting
  EP300 interacting inhibitor of differentiation 2
  EP300 interacting inhibitor of differentiation 2B
  EP300 interacting inhibitor of differentiation 3
  establishment of sister chromatid cohesion N-acetyltransferase 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  ETHE1 persulfide dioxygenase
  euchromatic histone lysine methyltransferase 1
  euchromatic histone lysine methyltransferase 2
  exosome component 7
  ezrin
  FEZ family zinc finger 2
  forkhead box G1
  forkhead box K1
  forkhead box K2
  forkhead box P3
  FOS like 1, AP-1 transcription factor subunit
  GATA zinc finger domain containing 1
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  glial cells missing transcription factor 1
  glutamate receptor interacting protein 1
  glycerol-3-phosphate acyltransferase, mitochondrial
  Gse1 coiled-coil protein
  H2A clustered histone 1
  H2A clustered histone 18
  H2A clustered histone 4
  H2B clustered histone 1
  H2B.U histone 1
  H3 clustered histone 1
  H3 clustered histone 6
  H3.4 histone
  H4 clustered histone 1
  HAUS augmin like complex subunit 2
  heat shock protein family A (Hsp70) member 4
  heat shock protein family D (Hsp60) member 1
  heat shock transcription factor 1
  helicase, lymphoid specific
  heparin binding growth factor
  hes family bHLH transcription factor 1
  hes related family bHLH transcription factor with YRPW motif 2
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  HIC ZBTB transcriptional repressor 1
  high mobility group 20A
  high mobility group 20B
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  histone deacetylase 5
  histone deacetylase 7
  histone deacetylase 9
  HMG-box transcription factor 1
  homeobox A11
  HR lysine demethylase and nuclear receptor corepressor
  HUS1 checkpoint clamp component
  hydroxysteroid 11-beta dehydrogenase 2
  hydroxysteroid dehydrogenase like 2
  hypoxia inducible factor 1 subunit alpha
  hypoxia inducible factor 1 subunit alpha inhibitor
  IKAROS family zinc finger 1
  IKAROS family zinc finger 2
  IKAROS family zinc finger 3
  importin 5
  inhibitor of growth family member 1
  inhibitor of growth family member 2
  INSM transcriptional repressor 1
  integrin alpha FG-GAP repeat containing 1
  interferon regulatory factor 5
  interferon related developmental regulator 1
  isocitrate dehydrogenase (NADP(+)) 2
  Jun dimerization protein 2
  Jun proto-oncogene, AP-1 transcription factor subunit
  karyopherin subunit alpha 1
  karyopherin subunit alpha 3
  karyopherin subunit alpha 4
  karyopherin subunit alpha 6
  kinase suppressor of ras 1
  Kruppel like factor 1
  Kruppel like factor 11
  Kruppel like factor 4
  L3MBTL histone methyl-lysine binding protein 2
  L3MBTL2 polycomb repressive complex 1 subunit
  La ribonucleoprotein 7, transcriptional regulator
  ligand dependent nuclear receptor corepressor
  LIM domain only 4
  lymphoid enhancer binding factor 1
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 4A
  lysine demethylase 4C
  lysine demethylase 5A
  lysine demethylase 5B
  lysine demethylase 5C
  lysine methyltransferase 2A
  lysine methyltransferase 2E (inactive)
  macroH2A.1 histone
  MAF bZIP transcription factor K
  MAGE family member A1
  MAGE family member A3
  MAGE family member B2
  MAX dimerization protein 1
  MAX dimerization protein MGA
  MAX interactor 1, dimerization protein
  MAX network transcriptional repressor
  Max protein
  MDM2 proto-oncogene
  mediator complex subunit 8
  membrane bound transcription factor peptidase, site 1
  menin 1
  metallothionein 1G
  metastasis associated 1
  metastasis associated 1
  metastasis associated 1 family member 2
  metastasis associated 1 family member 3
  metastasis-associated gene family, member 2
  methyl-CpG binding domain 4, DNA glycosylase
  methyl-CpG binding domain protein 2
  methyl-CpG binding domain protein 2
  methyl-CpG binding domain protein 3
  methyl-CpG binding domain protein 3 like 1
  methyl-CpG binding domain protein 3 like 2
  methyl-CpG binding protein 2
  methyltransferase like 3
  microtubule associated protein 1 light chain 3 beta
  MIER family member 2
  MIER family member 3
  MIER1 transcriptional regulator
  mitogen-activated protein kinase 10
  mitogen-activated protein kinase 11
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  mitotic arrest deficient 1 like 1
  mitotic deacetylase associated SANT domain protein
  mohawk homeobox
  mortality factor 4 like 1
  mortality factor 4 like 2
  MYC proto-oncogene, bHLH transcription factor
  myelin transcription factor 1
  myocyte enhancer factor 2A
  myocyte enhancer factor 2D
  myogenic differentiation 1
  NACC family member 2
  neurofibromin 2
  NFKB inhibitor alpha
  NK2 homeobox 1
  NK2 homeobox 2
  NK3 homeobox 1
  non-POU domain containing octamer binding
  notch receptor 1
  nuclear factor I X
  nuclear factor kappa B subunit 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear factor, erythroid 2 like 2
  nuclear receptor binding SET domain protein 2
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor interacting protein 1
  nuclear receptor interacting protein 1
  nuclear receptor subfamily 0 group B member 2
  nuclear receptor subfamily 1 group D member 2
  nuclear receptor subfamily 2 group C member 1
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 2 group E member 1
  nuclear receptor subfamily 2 group F member 2
  nuclear transcription factor Y subunit alpha
  nuclear transcription factor Y subunit beta
  nuclear transcription factor Y subunit gamma
  nucleolar and coiled-body phosphoprotein 1
  nucleophosmin 1
  nucleoporin 54
  nucleoporin 98 and 96 precursor
  nudix hydrolase 21
  ovo like transcriptional repressor 1
  ovo like zinc finger 2
  paired box 3
  paired like homeodomain 2
  Parkinsonism associated deglycase
  PBX homeobox 1
  peptidyl arginine deiminase 4
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peroxisomal biogenesis factor 10
  peroxisomal biogenesis factor 14
  peroxisome proliferator activated receptor delta
  peroxisome proliferator activated receptor gamma
  PH domain and leucine rich repeat protein phosphatase 1
  PHD finger protein 1
  PHD finger protein 12
  PHD finger protein 14
  PHD finger protein 20 like 1
  PHD finger protein 21A
  PHD finger protein 21B
  PHD finger protein 6
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  piggyBac transposable element derived 3
  PLAG1 like zinc finger 1
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  poly(A) polymerase alpha
  poly(ADP-ribose) polymerase 2
  polycomb group ring finger 6
  potassium channel tetramerization domain containing 11
  POU class 2 homeobox 1
  PR/SET domain 16
  PR/SET domain 4
  PR/SET domain 5
  PR/SET domain 6
  prefoldin subunit 2
  prefoldin subunit 5
  prefoldin subunit 6
  progesterone receptor membrane component 1
  prohibitin
  prohibitin 2
  proliferating cell nuclear antigen
  proline rich and Gla domain 4
  proteasomal ATPase associated factor 1
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 3
  protein inhibitor of activated STAT 4
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase cGMP-dependent 1
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  protein phosphatase 4 regulatory subunit 3A
  protein phosphatase 6 regulatory subunit 3
  prothymosin alpha
  PTOV1 extended AT-hook containing adaptor protein
  PWWP domain containing 2A
  PWWP domain containing 2B
  rabaptin, RAB GTPase binding effector protein 2
  RAD9 checkpoint clamp component A
  ralA binding protein 1
  RAP1A, member of RAS oncogene family
  RAR related orphan receptor C
  ras responsive element binding protein 1
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  RB transcriptional corepressor like 2
  RE1 silencing transcription factor
  recombination signal binding protein for immunoglobulin kappa J region
  RecQ like helicase 4
  regulatory factor X1
  regulatory factor X3
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 1
  replication factor C subunit 4
  replication initiator 1
  REST corepressor 1
  REST corepressor 2
  REST corepressor 3
  retinoic acid receptor alpha
  retinoic acid receptor beta
  retinol binding protein 1
  ring finger protein 1
  ring finger protein 123
  ring finger protein 138
  ring finger protein 157
  ring finger protein 2
  RING1 and YY1 binding protein
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA polymerase III subunit A
  RuvB like AAA ATPase 2
  SAM domain, SH3 domain and nuclear localization signals 1
  SAP30 like
  SATB homeobox 1
  SATB homeobox 2
  Scm like with four mbt domains 1
  SDS3 homolog, SIN3A corepressor complex component
  serine/threonine kinase receptor associated protein
  serpin family B member 5
  SET domain bifurcated histone lysine methyltransferase 1
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 2
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  SIN3 transcription regulator family member A
  SIN3 transcription regulator family member B
  Sin3A associated protein 130
  Sin3A associated protein 18
  Sin3A associated protein 30
  SIN3-HDAC complex associated factor
  SIN3-HDAC complex associated factor
  sirtuin 1
  sirtuin 6
  SKI like proto-oncogene
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  SMAD family member 5
  SMAD family member 7
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  snail family transcriptional repressor 2
  snail family transcriptional repressor 3
  sorting nexin 9
  Sp1 transcription factor
  Sp3 transcription factor
  spalt like transcription factor 1
  spen family transcriptional repressor
  Spi-1 proto-oncogene
  spleen associated tyrosine kinase
  splicing factor 3a subunit 1
  splicing factor proline and glutamine rich
  SRP receptor subunit alpha
  SRY-box transcription factor 2
  SRY-box transcription factor 6
  SS18 subunit of BAF chromatin remodeling complex
  SSX family member 2
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 4
  SUMO specific peptidase 1
  suppressor of variegation 3-9 homolog 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 6 like
  TATA-box binding protein associated factor, RNA polymerase I subunit B
  TBC1 domain family member 32
  TBL1X receptor 1
  T-box transcription factor 3
  t-complex 1
  TGFB induced factor homeobox 1
  TGFB induced factor homeobox 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  THAP domain containing 11
  thioredoxin interacting protein
  TLE family member 1, transcriptional corepressor
  TLE family member 3, transcriptional corepressor
  TLE family member 4, transcriptional corepressor
  TNF superfamily member 10
  TNFAIP3 interacting protein 1
  TPD52 like 1
  trafficking kinesin protein 1
  transcription factor 20
  transcription factor AP-4
  transcription factor CP2
  transcription factor Dp-1
  transcriptional adaptor 2A
  transcriptional regulating factor 1
  transcriptional regulator, SIN3A (yeast)
  transcriptional repressor GATA binding 1
  transient receptor potential cation channel subfamily M member 7
  translocase of inner mitochondrial membrane 13
  transmembrane protein 54
  trinucleotide repeat containing 18
  tripartite motif containing 21
  tripartite motif containing 27
  tripartite motif containing 28
  tRNA methyltransferase 61A
  tumor protein p53
  tumor protein p73
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 37
  ubiquitin specific peptidase 43
  ubiquitin specific peptidase 7
  upstream binding transcription factor
  VHL binding protein 1
  vimentin
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WD repeat domain 5
  WIZ zinc finger
  WRN RecQ like helicase
  WW domain containing E3 ubiquitin protein ligase 2
  xylosyltransferase 2
  Yes1 associated transcriptional regulator
  YY1 transcription factor
  ZFP36 ring finger protein
  ZFP64 zinc finger protein
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 2
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type and G-patch domain containing
  zinc finger E-box binding homeobox 2
  zinc finger MYM-type containing 2
  zinc finger MYM-type containing 3
  zinc finger MYND-type containing 11
  zinc finger MYND-type containing 8
  zinc finger protein 148
  zinc finger protein 217
  zinc finger protein 219
  zinc finger protein 273
  zinc finger protein 395
  zinc finger protein 512B
  zinc finger protein 516
  zinc finger protein 521
  zinc finger protein 592
  zinc finger protein 608
  zinc finger protein 609
  zinc finger protein 639
  zinc finger protein 687
  zinc finger protein 76
  zinc finger protein 800
  zinc finger protein 827
  zinc finger protein, FOG family member 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.