CEBPA, CCAAT enhancer binding protein alpha

CEBPA, CCAAT enhancer binding protein alpha

• This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

• Gene Synonyms (CCAAT/enhancer-binding protein alpha, CCAAT/enhancer binding protein (C/EBP), alpha, C/EBP-alpha, CEBP,)
• NCBI Gene ID: 1050
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49715
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CCAAT enhancer binding protein alpha interacts with:

• activating transcription factor 2
  activating transcription factor 5
  adenylate kinase 5
  A-kinase anchoring protein 9
  ASXL transcriptional regulator 1
  basic helix-loop-helix family member e41
  basic leucine zipper ATF-like transcription factor
  basic leucine zipper ATF-like transcription factor 2
  basic leucine zipper ATF-like transcription factor 3
  catenin beta 1
  CCAAT enhancer binding protein alpha
  CCAAT enhancer binding protein beta
  CCAAT enhancer binding protein delta
  CCAAT enhancer binding protein epsilon
  CCAAT enhancer binding protein gamma
  chromodomain helicase DNA binding protein 1
  coiled-coil domain containing 183
  COP1 E3 ubiquitin ligase
  CREB binding protein
  D-box binding PAR bZIP transcription factor
  decapping enzyme, scavenger
  DNA damage inducible transcript 3
  E1A binding protein p300
  E2F transcription factor 4
  ELAV like RNA binding protein 1
  endothelial differentiation related factor 1
  estrogen receptor 1
  EWS RNA binding protein 1
  F-box and WD-40 domain protein 7
  FOS like 1, AP-1 transcription factor subunit
  Fos proto-oncogene, AP-1 transcription factor subunit
  fucosyltransferase 1 (H blood group)
  GATA binding protein 2
  glial fibrillary acidic protein
  glutamate ionotropic receptor NMDA type subunit 3A
  glycogen synthase kinase 3 beta
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein C
  histone deacetylase 1
  histone deacetylase 2
  HNF1 homeobox A
  hypoxia inducible factor 1 subunit alpha
  Jun proto-oncogene, AP-1 transcription factor subunit
  lactotransferrin
  lysine acetyltransferase 5
  MAF bZIP transcription factor
  MAX network transcriptional repressor
  membrane palmitoylated protein 2
  microtubule actin crosslinking factor 1
  minichromosome maintenance complex component 5
  mitogen-activated protein kinase 8
  MRT4 homolog, ribosome maturation factor
  msh homeobox 2
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  N-alpha-acetyltransferase 16, NatA auxiliary subunit
  nuclear factor of activated T cells 4
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor subfamily 1 group I member 2
  nuclear receptor subfamily 3 group C member 1
  nuclear transcription factor Y subunit alpha
  phosphoglycerate mutase 1
  proteasome 26S subunit, non-ATPase 10
  protein inhibitor of activated STAT 1
  protein kinase N2
  protein phosphatase 2 catalytic subunit alpha
  RAB34, member RAS oncogene family
  RAN binding protein 2
  Ras protein specific guanine nucleotide releasing factor 1
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  replication factor C subunit 1
  retinoic acid receptor alpha
  retinoic acid receptor beta
  RNA polymerase I subunit E
  RPGR interacting protein 1
  SMAD family member 3
  SMAD family member 4
  small ubiquitin like modifier 3
  solute carrier family 25 member 11
  SP110 nuclear body protein
  spectrin beta, non-erythrocytic 1
  S-phase kinase associated protein 2
  Spi-1 proto-oncogene
  splicing factor proline and glutamine rich
  SRY-box transcription factor 10
  SRY-box transcription factor 8
  steroid receptor RNA activator 1
  structural maintenance of chromosomes 1A
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  transformer 2 beta homolog
  transforming growth factor beta 2
  tribbles pseudokinase 1
  ubiquitin protein ligase E3A
  vacuolar protein sorting 72 homolog
  vitamin D receptor
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  YY1 associated protein 1
  zinc finger and BTB domain containing 16
  zinc finger E-box binding homeobox 2
  zinc finger protein 45

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.