FOS, Fos proto-oncogene, AP-1 transcription factor subunit

FOS, Fos proto-oncogene, AP-1 transcription factor subunit

• The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AP-1, C-FOS, p55, proto-oncogene c-Fos, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, Fos proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 7, activator protein 1, cellular oncogene c-fos,)
• NCBI Gene ID: 2353
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P01100
  UNIPROT ID#>>Q6FG41
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fos proto-oncogene, AP-1 transcription factor subunit interacts with:

• acidic nuclear phosphoprotein 32 family member E
  activating transcription factor 7
  ADP ribosylation factor GTPase activating protein 1
  ADP ribosylation factor like GTPase 6 interacting protein 4
  ankyrin repeat and KH domain containing 1
  ankyrin repeat domain 17
  anti-silencing function 1A histone chaperone
  basic leucine zipper ATF-like transcription factor
  calcium binding protein 1
  cAMP responsive element binding protein 5
  centromere protein O
  checkpoint kinase 2
  cilia and flagella associated protein 57
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 120
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 4
  cytohesin 4
  DEAD-box helicase 17
  DET1 partner of COP1 E3 ubiquitin ligase
  DNA methyltransferase 3 like
  enkurin domain containing 1
  FA core complex associated protein 100
  formin binding protein 1 like
  Fos proto-oncogene, AP-1 transcription factor subunit
  FosB proto-oncogene, AP-1 transcription factor subunit
  G protein subunit gamma 11
  galactosidase beta 1
  GATA binding protein 4
  general transcription factor IIE subunit 2
  general transcription factor IIF subunit 1
  general transcription factor IIF subunit 2
  glyoxalase I
  glyoxylate and hydroxypyruvate reductase
  guanidinoacetate N-methyltransferase
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 1A
  histone cell cycle regulator
  HNF1 homeobox A
  homeobox D13
  hydroxysteroid 17-beta dehydrogenase 4
  hypoxia inducible factor 1 subunit alpha
  interleukin 11
  Jun proto-oncogene, AP-1 transcription factor subunit
  JunB proto-oncogene, AP-1 transcription factor subunit
  JunD proto-oncogene, AP-1 transcription factor subunit
  kelch repeat and BTB domain containing 7
  KH-type splicing regulatory protein
  lamin A/C
  leucine zipper protein 4
  LIM domain 7
  LIM domain only 3
  LIM domain only 7
  lysine demethylase 2A
  lysine demethylase 2B
  MAF bZIP transcription factor
  MAF bZIP transcription factor B
  MAF bZIP transcription factor F
  mediator complex subunit 17
  melanocyte inducing transcription factor
  microtubule associated protein 1B
  mitochondrial transcription termination factor 4
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 7
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase kinase 7
  MYC associated zinc finger protein
  myotubularin related protein 1
  nascent polypeptide associated complex subunit alpha
  negative elongation factor complex member B
  neurofilament medium
  nuclear factor I X
  nuclear factor kappa B subunit 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear factor of activated T cells 2 interacting protein
  nuclear factor of activated T cells 3
  nuclear factor of activated T cells 5
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group F member 1
  optineurin
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  PML nuclear body scaffold
  proteasome 26S subunit, ATPase 5
  proteasome subunit alpha 4
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 12A
  RB transcriptional corepressor 1
  RELA proto-oncogene, NF-kB subunit
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A4
  RNA polymerase II, I and III subunit E
  schwannomin interacting protein 1
  serine/threonine kinase 40
  serum response factor
  SET nuclear proto-oncogene
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  sirtuin 1
  SMAD family member 3
  small ubiquitin like modifier 1
  small ubiquitin like modifier 2
  small ubiquitin like modifier 3
  small ubiquitin like modifier 4
  Spi-1 proto-oncogene
  SSU72 homolog, RNA polymerase II CTD phosphatase
  steroid receptor RNA activator 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  TATA-box binding protein
  TATA-box binding protein associated factor 1
  TCL1 family AKT coactivator A
  terminal nucleotidyltransferase 5B
  tetraspanin 2
  trafficking protein particle complex 13
  tribbles pseudokinase 1
  trophinin
  ubinuclein 1
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L3
  ubiquitin protein ligase E3 component n-recognin 1
  upstream transcription factor 1
  upstream transcription factor 2, c-fos interacting
  UTP4 small subunit processome component
  valyl-tRNA synthetase 1
  vascular endothelial growth factor A
  vitamin D receptor
  X-box binding protein 1
  YEATS domain containing 4
  zinc finger protein 133

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.