IRS1, insulin receptor substrate 1

IRS1, insulin receptor substrate 1

• This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

• Gene Synonyms (HIRS-1, insulin receptor substrate 1,)
• NCBI Gene ID: 3667
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R499
  UNIPROT ID#>>P35568
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin receptor substrate 1 interacts with:

• 3-phosphoinositide dependent protein kinase 1
  BCAR3 adaptor protein, NSP family member
  beta-transducin repeat containing E3 ubiquitin protein ligase
  CD2 associated protein
  cullin 1
  cullin 7
  egl-9 family hypoxia inducible factor 3
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 8
  F-box protein 25
  growth factor receptor bound protein 2
  insulin receptor substrate 1
  insulin receptor substrate 2
  Janus kinase 1
  Janus kinase 2
  Janus kinase 3
  KH RNA binding domain containing, signal transduction associated 1
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  NCK adaptor protein 2
  NEDD4 E3 ubiquitin protein ligase
  neurotrophic receptor tyrosine kinase 1
  nischarin
  nucleophosmin 1
  NUMB endocytic adaptor protein
  PAS domain containing serine/threonine kinase
  pellino E3 ubiquitin protein ligase 1
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 2
  pleckstrin homology domain interacting protein
  protein kinase C delta
  protein kinase C gamma
  protein kinase C theta
  protein kinase C zeta
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase receptor type C
  protein tyrosine phosphatase receptor type D
  protein tyrosine phosphatase receptor type F
  protein tyrosine phosphatase receptor type U
  RAD51 recombinase
  regulatory associated protein of MTOR complex 1
  Rho associated coiled-coil containing protein kinase 1
  ribosomal protein S6 kinase B1
  ring finger protein 123
  ring finger protein 4
  salt inducible kinase 2
  salt inducible kinase 2
  SH2B adaptor protein 1
  SHC adaptor protein 1
  sirtuin 1
  SMAD family member 3
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  synaptophysin
  transformation related protein 53
  transformed mouse 3T3 cell double minute 2
  tripartite motif containing 72
  TUB bipartite transcription factor
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase 2
  ubiquitin C
  ubiquitin specific peptidase 9 X-linked
  upstream binding transcription factor
  vir like m6A methyltransferase associated
  zinc finger DHHC-type palmitoyltransferase 18
  zinc finger DHHC-type palmitoyltransferase 23

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.