CDC25A, cell division cycle 25A

CDC25A, cell division cycle 25A

• CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (M-phase inducer phosphatase 1, CDC25 isoform A1-CAG, CDC25A2-CAG isoform, dual specificity phosphatase CDC25A, CDC25A2,)
• NCBI Gene ID: 993
• Species: Homo sapiens (Human)
• UNIPROT ID#>>K7N7S0
  UNIPROT ID#>>A0A024R2S4
  UNIPROT ID#>>A0A024R2R6
  UNIPROT ID#>>P30304
  UNIPROT ID#>>D8KXX0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cell division cycle 25A interacts with:

• adenosylhomocysteinase like 1
  ankyrin repeat domain 28
  apolipoprotein L domain containing 1
  ataxin 7 like 3B
  beta-transducin repeat containing E3 ubiquitin protein ligase
  calcium/calmodulin dependent protein kinase ID
  casein kinase 1 alpha 1
  casein kinase 1 gamma 2
  cell division cycle 25A
  checkpoint kinase 1
  checkpoint kinase 2
  coiled-coil domain containing 28A
  COPI coat complex subunit beta 2
  COPI coat complex subunit gamma 1
  cullin 1
  cullin 3
  cut like homeobox 1
  cyclin A1
  cyclin dependent kinase 2
  cyclin dependent kinase 3
  cyclin dependent kinase 5
  cyclin dependent kinase inhibitor 1A
  cyclin dependent kinase inhibitor 3
  cyclin I
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 7
  DLG associated protein 3
  DnaJ heat shock protein family (Hsp40) member C10
  dual specificity phosphatase 7
  dual specificity phosphatase 8
  dystrophin
  E2F transcription factor 1
  E2F transcription factor 2
  E2F transcription factor 3
  E2F transcription factor 4
  egl-9 family hypoxia inducible factor 3
  epidermal growth factor receptor
  erb-b2 receptor tyrosine kinase 2
  ETAA1 activator of ATR kinase
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation elongation factor 1 alpha 1
  exportin 1
  family with sequence similarity 193 member B
  family with sequence similarity 91 member A1
  fatty acid binding protein 4
  F-box and WD repeat domain containing 11
  ferritin heavy chain 1
  fibroblast growth factor 21
  fibroblast growth factor receptor 3
  fizzy and cell division cycle 20 related 1
  four and a half LIM domains 1
  general transcription factor IIi
  golgi associated PDZ and coiled-coil motif containing
  high mobility group AT-hook 1
  histone deacetylase 11
  HRas proto-oncogene, GTPase
  hypocretin neuropeptide precursor
  importin 5
  interleukin 3 receptor subunit alpha
  leucine rich pentatricopeptide repeat containing
  LIM domain only 2
  major histocompatibility complex, class I, C
  metastasis associated 1 family member 2
  methylthioadenosine phosphorylase
  minichromosome maintenance complex binding protein
  minichromosome maintenance complex component 3 associated protein
  minichromosome maintenance complex component 6
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase kinase kinase 5
  N-alpha-acetyltransferase 10, NatA catalytic subunit
  N-alpha-acetyltransferase 11, NatA catalytic subunit
  NFKB inhibitor beta
  NPL4 homolog, ubiquitin recognition factor
  nuclear RNA export factor 1
  nuclear transcription factor Y subunit alpha
  nucleoporin 188
  oxytocin/neurophysin I prepropeptide
  peroxisomal biogenesis factor 19
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  Pim-1 proto-oncogene, serine/threonine kinase
  PNMA family member 2
  potassium channel tetramerization domain containing 12
  protein disulfide isomerase family A member 3
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase C delta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase 4 regulatory subunit 3A
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  protein tyrosine phosphatase 4A1
  pyruvate kinase M1/2
  RAD23 homolog A, nucleotide excision repair protein
  Raf-1 proto-oncogene, serine/threonine kinase
  RB binding protein 7, chromatin remodeling factor
  RELA proto-oncogene, NF-kB subunit
  Rho associated coiled-coil containing protein kinase 1
  RNA polymerase I and III subunit D
  SCY1 like pseudokinase 1
  SMAD family member 3
  solute carrier family 16 member 8
  S-phase kinase associated protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 5
  stratifin
  stress induced phosphoprotein 1
  tribbles pseudokinase 3
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin B
  ubiquitin specific peptidase 11
  ubiquitination factor E4B
  valosin containing protein
  vesicle associated membrane protein 8
  WD repeat domain 11
  WD repeat domain 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.