AKT2, AKT serine/threonine kinase 2

AKT2, AKT serine/threonine kinase 2

• This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

• Gene Synonyms (RAC-beta serine/threonine-protein kinase, PKB beta, RAC-PK-beta, murine thymoma viral (v-akt) homolog-2, protein kinase Akt-2, protein kinase B beta, putative v-akt murine thymoma viral oncoprotein 2, rac protein kinase beta, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA,)
• NCBI Gene ID: 208
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DG79
  UNIPROT ID#>>P31751
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AKT serine/threonine kinase 2 interacts with:

• 3-hydroxy-3-methylglutaryl-CoA reductase
  3-phosphoinositide dependent protein kinase 1
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  adaptor related protein complex 4 subunit mu 1
  AKT serine/threonine kinase 2
  AKT1 substrate 1
  amyloid beta precursor protein
  apolipoprotein A1
  apolipoprotein B
  ATP binding cassette subfamily G member 8
  biliverdin reductase A
  CAP-Gly domain containing linker protein 3
  C-C motif chemokine ligand 14
  C-terminal Src kinase
  cullin 1
  cyclin dependent kinase 12
  cyclin dependent kinase 3
  cyclin dependent kinase 5
  cyclin dependent kinase inhibitor 1A
  egl-9 family hypoxia inducible factor 1
  epidermal growth factor receptor
  estrogen receptor 1
  eukaryotic translation initiation factor 4E binding protein 1
  FAT atypical cadherin 3
  FKBP prolyl isomerase 5
  follicle stimulating hormone receptor
  forkhead box O4
  G protein subunit beta 1
  G protein-coupled receptor kinase 5
  glutamate metabotropic receptor 2
  glycogen synthase kinase 3 beta
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  growth hormone secretagogue receptor
  H3 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  mature T cell proliferation 1
  mesenchyme homeobox 2
  neurotrophic receptor tyrosine kinase 1
  nicotinamide phosphoribosyltransferase
  NSE4 homolog A, SMC5-SMC6 complex component
  nuclear receptor subfamily 2 group F member 2
  patatin like phospholipase domain containing 3
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
  phosphofructokinase, platelet
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing O1
  proteasome 26S subunit, non-ATPase 9
  protein interacting with PRKCA 1
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein O-fucosyltransferase 1
  protein phosphatase 2 catalytic subunit alpha
  RAB3D, member RAS oncogene family
  Rac GTPase activating protein 1
  REL proto-oncogene, NF-kB subunit
  ribulose-5-phosphate-3-epimerase
  RNA polymerase I subunit B
  SET domain bifurcated histone lysine methyltransferase 1
  SH3 domain containing ring finger 1
  SKI proto-oncogene
  small proline rich protein 2A
  snail family transcriptional repressor 1
  solute carrier family 2 member 4
  sorbin and SH3 domain containing 2
  sorbin and SH3 domain containing 3
  sorting nexin 27
  STEAP4 metalloreductase
  TCL1 family AKT coactivator A
  TCL1 family AKT coactivator B
  tetratricopeptide repeat domain 3
  transmembrane p24 trafficking protein 2
  transmembrane protein 17
  tribbles pseudokinase 3
  tropomyosin 2
  ubiquitin B
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L1
  ubiquitin specific peptidase 9 Y-linked
  vimentin
  von Hippel-Lindau tumor suppressor
  WD repeat domain 26

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.