CSE1L, chromosome segregation 1 like

CSE1L, chromosome segregation 1 like

• Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

• Gene Synonyms (exportin-2, CSE1 chromosome segregation 1-like, cellular apoptosis susceptibility protein, chromosome segregation 1-like protein, epididymis secretory sperm binding protein, exp2, importin-alpha re-exporter, CAS, CSE1, XPO2,)
• NCBI Gene ID: 1434
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55060
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chromosome segregation 1 like interacts with:

• 3-hydroxyacyl-CoA dehydratase 1
  AAR2 splicing factor
  aminopeptidase puromycin sensitive
  ankyrin repeat and SOCS box containing 16
  anterior gradient 2, protein disulphide isomerase family member
  aspartyl-tRNA synthetase 1
  ataxin 3
  BRCA2 and CDKN1A interacting protein
  carnosine dipeptidase 2
  cell division cycle 73
  coiled-coil domain containing 8
  CYLD lysine 63 deubiquitinase
  cysteine and histidine rich domain containing 1
  cytochrome b5 type B
  developmental pluripotency-associated 3
  dual specificity phosphatase 16
  dual specificity phosphatase 23
  E1A binding protein p300
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  epidermal growth factor receptor
  ER lipid raft associated 2
  estrogen receptor 1
  eukaryotic translation elongation factor 2
  exportin 1
  Fas associated factor family member 2
  F-box and WD repeat domain containing 7
  F-box protein 25
  F-box protein 6
  fibronectin 1
  forkhead box A1
  FUS RNA binding protein
  G3BP stress granule assembly factor 1
  GINS complex subunit 3
  glycogen synthase kinase 3 beta
  guanine deaminase
  H2A clustered histone 4
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 5
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein L
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  histone deacetylase 6
  importin 5
  integrin subunit alpha 4
  karyopherin subunit alpha 1
  karyopherin subunit alpha 2
  karyopherin subunit alpha 4
  karyopherin subunit alpha 6
  karyopherin subunit beta 1
  kinesin family member 18A
  KRAS proto-oncogene, GTPase
  kynureninase
  lactate dehydrogenase A
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  melatonin receptor 1B
  membrane spanning 4-domains A4A
  methylthioadenosine phosphorylase
  mevalonate diphosphate decarboxylase
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 6
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Mtr4 exosome RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  NK2 homeobox 1
  nuclear factor of activated T cells 2
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin RBR E3 ubiquitin protein ligase
  phosphoglycerate kinase 1
  phospholipase A2 activating protein
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 4
  proteasome activator subunit 1
  protein disulfide isomerase family A member 3
  protein phosphatase 5 catalytic subunit
  protein phosphatase 6 catalytic subunit
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase mitochondrial 1
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type E
  protein tyrosine phosphatase receptor type H
  protein tyrosine phosphatase receptor type M
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type U
  protocadherin 1
  proton activated chloride channel 1
  PTEN induced kinase 1
  pyrimidinergic receptor P2Y6
  RAD18 E3 ubiquitin protein ligase
  RAN, member RAS oncogene family
  Ras related GTP binding B
  RecQ like helicase 4
  ribosomal protein L22
  ribosomal protein S6 kinase A3
  ring finger protein 144A
  ring finger protein 181
  ring finger protein 2
  ring finger protein 4
  RIO kinase 1
  RP2 activator of ARL3 GTPase
  selenocysteine lyase
  signal transducer and activator of transcription 1
  sirtuin 7
  SLC9A3 regulator 1
  snail family transcriptional repressor 1
  SNW domain containing 1
  spermine synthase
  spindle apparatus coiled-coil protein 1
  staufen double-stranded RNA binding protein 1
  stomatin
  sulfotransferase family 1C member 3
  sulfotransferase family 1C member 4
  SUZ12 polycomb repressive complex 2 subunit
  testis expressed 101
  thioredoxin domain containing 5
  thioredoxin like 1
  TNF superfamily member 13b
  TOR signaling pathway regulator
  transcription elongation factor A1
  transglutaminase 2
  transmembrane phosphatase with tensin homology
  transmembrane protein 171
  transmembrane protein 62
  tripeptidyl peptidase 2
  twinfilin actin binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquilin 2
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin family domain containing 1
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin specific peptidase 1
  ubiquitin specific peptidase 19
  UBX domain protein 1
  unc-45 myosin chaperone A
  unc-93 homolog B1, TLR signaling regulator
  unk zinc finger
  vascular cell adhesion molecule 1
  vesicle associated membrane protein 5
  vir like m6A methyltransferase associated
  V-set and immunoglobulin domain containing 2
  WD repeat domain 5
  WD repeat domain 76
  X-prolyl aminopeptidase 1
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.