HSPA1A, heat shock protein family A (Hsp70) member 1A

HSPA1A, heat shock protein family A (Hsp70) member 1A

• This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

• Gene Synonyms (heat shock 70 kDa protein 1A, HSP70-1/HSP70-2, HSP70.1/HSP70.2, Heat shock 70 kDa protein 1B, Heat shock 70 kDa protein 2, dnaK-type molecular chaperone HSP70-1, epididymis secretory protein Li 103, epididymis secretory sperm binding protein, heat shock 70 kDa protein 1, heat shock 70 kDa protein 1/2, heat shock 70 kDa protein 1A/1B, heat shock 70kD protein 1A, heat shock 70kDa protein 1A, heat shock-induced protein, HEL-S-103, HSP70-1, HSP70-1A, HSP70-2, HSP70.1, HSP70.2, HSP70I, HSP72, HSPA1,)
• NCBI Gene ID: 3303
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K5I0
  UNIPROT ID#>>B3KTT5
  UNIPROT ID#>>P0DMV8
  UNIPROT ID#>>P0DMV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family A (Hsp70) member 1A interacts with:

• AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  AKT interacting protein
  ankyrin repeat and SOCS box containing 10
  ankyrin repeat and SOCS box containing 16
  anoctamin 7
  apoptosis inducing factor mitochondria associated 1
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
  argonaute RISC component 4
  ataxin 1
  ataxin 10
  ataxin 3
  aurora kinase A
  aurora kinase B
  BAG cochaperone 2
  BAG cochaperone 3
  BAG cochaperone 4
  BAG cochaperone 6
  BCL2-associated athanogene 2
  beclin 1
  Bet1 golgi vesicular membrane trafficking protein
  BR serine/threonine kinase 1
  BRCA1 associated protein 1
  bromodomain containing 7
  calcium regulated heat stable protein 1
  CD96 molecule
  cell division cycle 37 like 1
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 250
  centrosomal protein 57
  centrosomal protein 72
  centrosomal protein 76
  cerberus 1, DAN family BMP antagonist
  chromosome 17 open reading frame 49
  cilia and flagella associated protein 52
  clusterin associated protein 1
  contactin associated protein 1
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin associated and neddylation dissociated 1
  defective in cullin neddylation 1 domain containing 1
  DIS3 like exosome 3'-5' exoribonuclease
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member A4
  DnaJ heat shock protein family (Hsp40) member B1
  DnaJ heat shock protein family (Hsp40) member B11
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member B5
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member B7
  DnaJ heat shock protein family (Hsp40) member B8
  DnaJ heat shock protein family (Hsp40) member C17
  DnaJ heat shock protein family (Hsp40) member C3
  DnaJ heat shock protein family (Hsp40) member C7
  dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  dual specificity tyrosine phosphorylation regulated kinase 2
  dynein axonemal assembly factor 4
  Ecm29 proteasome adaptor and scaffold
  elongation factor Tu GTP binding domain containing 2
  ERBB receptor feedback inhibitor 1
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 6
  ezrin
  F-box protein 6
  FCH and double SH3 domains 1
  forkhead box P3
  formin binding protein 1
  galectin 3 binding protein
  GCN1 activator of EIF2AK4
  gigaxonin
  H2A clustered histone 4
  H3 clustered histone 15
  H4 clustered histone 1
  HAUS augmin like complex subunit 1
  HAUS augmin like complex subunit 2
  heat shock 105kDa/110kDa protein 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family D (Hsp60) member 1
  hemogen
  hes related family bHLH transcription factor with YRPW motif 1
  histone acetyltransferase 1
  histone deacetylase 4
  histone deacetylase 5
  homeodomain interacting protein kinase 2
  HSPA (Hsp70) binding protein 1
  huntingtin associated protein 1
  huntingtin interacting protein K
  inhibitor of DNA binding 2
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin
  insulin induced gene 2
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  interferon regulatory factor 1
  interleukin enhancer binding factor 2
  ISG15 ubiquitin like modifier
  katanin catalytic subunit A1
  keratin 18
  keratin 7
  kinetochore localized astrin (SPAG5) binding protein
  La ribonucleoprotein 7, transcriptional regulator
  lectin, mannose binding 1
  leucine rich repeat kinase 2
  LIM domain binding 3
  lysine demethylase 1A
  macrophage scavenger receptor 1
  mago homolog, exon junction complex subunit
  matrin 3
  MCL1 apoptosis regulator, BCL2 family member
  mediator complex subunit 12
  membrane metalloendopeptidase
  metal regulatory transcription factor 1
  methyltransferase like 14
  methyltransferase like 21A
  methyltransferase like 3
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein RP/EB family member 1
  microtubule associated protein tau
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitofusin 2
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase kinase 21
  mitogen-activated protein kinase kinase kinase 5
  MOS proto-oncogene, serine/threonine kinase
  Myb like, SWIRM and MPN domains 1
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin, heavy polypeptide 3, skeletal muscle, embryonic
  NEDD1 gamma-tubulin ring complex targeting factor
  NEDD8 ubiquitin like modifier
  neurotrophic receptor tyrosine kinase 1
  non-POU domain containing octamer binding
  NSFL1 cofactor
  nuclear factor of activated T cells 2
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin RBR E3 ubiquitin protein ligase
  paxillin
  peptidylprolyl isomerase A
  peptidylprolyl isomerase D
  peroxisomal biogenesis factor 5
  phosphatase and tensin homolog
  phosphatidylinositol 3-kinase catalytic subunit type 3
  PIH1 domain containing 1
  plasminogen
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  potassium voltage-gated channel subfamily H member 2
  pre-mRNA processing factor 8
  progesterone receptor
  proline-serine-threonine phosphatase interacting protein 1
  prostaglandin E synthase 3
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, non-ATPase 14
  protection of telomeres 1
  protein kinase C alpha
  protein kinase C and casein kinase substrate in neurons 1
  protein kinase C and casein kinase substrate in neurons 2
  protein kinase C and casein kinase substrate in neurons 3
  protein phosphatase 1 regulatory subunit 15A
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 6 catalytic subunit
  protein tyrosine phosphatase receptor type F
  prothymosin alpha
  PTEN induced kinase 1
  RAB11A, member RAS oncogene family
  RAB9A, member RAS oncogene family
  Rap guanine nucleotide exchange factor 2
  RAP1A, member of RAS oncogene family
  RE1 silencing transcription factor
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  required for meiotic nuclear division 5 homolog A
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 207
  ring finger protein 31
  ring-box 1
  RIO kinase 1
  serine and arginine rich splicing factor 2
  serine/arginine repetitive matrix 2
  serine/threonine kinase 11
  SET domain containing 1A, histone lysine methyltransferase
  SH2 domain containing 1B
  SHC adaptor protein 1
  signal regulatory protein alpha
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 2
  SNF related kinase
  solute carrier family 12 member 3
  solute carrier family 13 member 1
  solute carrier family 5 member 1
  solute carrier family 6 member 4
  spermatogenesis associated 5 like 1
  spindle apparatus coiled-coil protein 1
  SprT-like N-terminal domain
  SRY-box transcription factor 9
  ST13 Hsp70 interacting protein
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stomatin like 2
  stress induced phosphoprotein 1
  SUMO1 activating enzyme subunit 1
  SUZ12 polycomb repressive complex 2 subunit
  synuclein alpha
  synuclein beta
  TATA-box binding protein associated factor 15
  T-box transcription factor 3
  telomerase reverse transcriptase
  testis specific serine kinase 6
  tet methylcytosine dioxygenase 2
  tetratricopeptide repeat domain 1
  thioredoxin interacting protein
  TNFAIP3 interacting protein 2
  TP53 regulated inhibitor of apoptosis 1
  TRAF3 interacting protein 1
  transcription elongation regulator 1
  transcription factor CP2
  transforming growth factor beta 1
  transglutaminase 2
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 70
  tripartite motif containing 24
  tripartite motif containing 25
  tripartite motif containing 29
  tripartite motif containing 38
  tubulin alpha 4a
  tubulin beta class I
  tubulin gamma 1
  tubulin gamma complex associated protein 2
  tubulin gamma complex associated protein 3
  tubulin gamma complex associated protein 4
  tumor protein p53
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 4A
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 43
  ubiquitin specific peptidase 50
  UBX domain protein 6
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  von Willebrand factor C and EGF domains
  VRK serine/threonine kinase 3
  WD repeat domain 76
  WT1 associated protein
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 7A
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.