CRY1, cryptochrome circadian regulator 1

CRY1, cryptochrome circadian regulator 1

• This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

• Gene Synonyms (cryptochrome-1, cryptochrome 1 (photolyase-like), cryptochrome circadian clock 1, DSPD, PHLL1,)
• NCBI Gene ID: 1407
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A2I2P0
  UNIPROT ID#>>Q16526
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cryptochrome circadian regulator 1 interacts with:

• arginyl-tRNA synthetase 1
  ariadne RBR E3 ubiquitin protein ligase 1
  aspartyl-tRNA synthetase 1
  BAG cochaperone 6
  BAR/IMD domain containing adaptor protein 2
  basic helix-loop-helix family member e41
  beta-transducin repeat containing E3 ubiquitin protein ligase
  casein kinase 1 delta
  casein kinase 1 epsilon
  casein kinase 1, epsilon
  casein kinase 2 alpha 1
  casein kinase 2 beta
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 8
  clock circadian regulator
  cryptochrome 1 (photolyase-like)
  cryptochrome circadian regulator 1
  cryptochrome circadian regulator 2
  cullin 1
  DET1 partner of COP1 E3 ubiquitin ligase
  DnaJ heat shock protein family (Hsp40) member A1
  elongation factor Tu GTP binding domain containing 2
  estrogen related receptor, beta
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 4A1
  eukaryotic translation initiation factor 4A2
  exportin 1
  fatty acid synthase
  F-box and leucine rich repeat protein 3
  filamin A
  forkhead box O1
  glutamyl-prolyl-tRNA synthetase 1
  glycyl-tRNA synthetase 1
  granulin precursor
  guanine monophosphate synthase
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 5
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H2
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein U
  inner membrane mitochondrial protein
  inosine monophosphate dehydrogenase 2
  interleukin enhancer binding factor 3
  isoleucyl-tRNA synthetase 1
  Janus kinase 3
  karyopherin subunit beta 1
  keratin 10
  keratin 2
  keratin associated protein 4-12
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 20B
  latent transforming growth factor beta binding protein 4
  leucine rich pentatricopeptide repeat containing
  matrin 3
  methionyl-tRNA synthetase 1
  methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 4
  minichromosome maintenance complex component 7
  MYC binding protein 2
  MyoD family inhibitor
  NADH:ubiquinone oxidoreductase core subunit S3
  NEDD1 gamma-tubulin ring complex targeting factor
  neuronal PAS domain protein 2
  nuclear autoantigenic sperm protein
  nuclear receptor subfamily 1 group D member 2
  nucleophosmin 1
  period circadian regulator 1
  period circadian regulator 2
  period circadian regulator 3
  peroxiredoxin 1
  peroxiredoxin 4
  phospholipid scramblase 1
  phosphoribosyl pyrophosphate amidotransferase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 3
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 1
  polypyrimidine tract binding protein 1
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 3
  protein arginine methyltransferase 5
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 regulatory subunit B'delta
  protein phosphatase 2 regulatory subunit B'epsilon
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  pyruvate kinase M1/2
  quinolinate phosphoribosyltransferase
  regulator of G protein signaling 20
  ribosomal protein L10
  ribosomal protein S14
  ribosomal protein S27a
  ribosomal protein S3
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  SCY1 like pseudokinase 2
  sestrin 2
  small nuclear ribonucleoprotein D3 polypeptide
  S-phase kinase associated protein 1
  splicing factor proline and glutamine rich
  succinate dehydrogenase complex flavoprotein subunit A
  synaptotagmin binding cytoplasmic RNA interacting protein
  t-complex 1
  tektin 4
  thioredoxin
  timeless circadian clock 1
  timeless circadian regulator
  TNF receptor associated factor 2
  trimethylguanosine synthase 1
  tripartite motif containing 28
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin B
  ubiquitin like modifier activating enzyme 1
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 7
  ubiquitin specific peptidase 9 X-linked
  WD repeat domain 77
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.